脂联素基因多态性对高龄相关性黄斑变性风险的影响。
Effects of adiponectin polymorphisms on the risk of advanced age-related macular degeneration.
作者信息
Cao Guiqun, Chen Yulong, Zhang Jinlong, Liu Yulan, Zhang Ming, Zhang Kang, Su Zhiguang
机构信息
a Molecular Medicine Research Center, State Key Laboratory of Biotherapy and.
出版信息
Biomarkers. 2015;20(4):266-70. doi: 10.3109/1354750X.2015.1068857.
OBJECTIVE
To determine the relationships between variants in adiponectin gene (ADIPOQ) with advanced forms of age-related macular degeneration (AMD) susceptibility.
METHODS
A total of 189 advanced AMD patients and 168 controls were recruited. Seven tagging single-nucleotide polymorphisms in ADIPOQ were genotyped by the SNaPshot method.
RESULTS
Alleles or genotypes of rs822396 distributed significantly differently in advanced AMD patients and controls. The minor allele G at rs822396 was associated with an increased risk of advanced AMD in a dominant model. Furthermore, haplotype analysis revealed that haplotypes AGGACCT and TGACCCC were significantly increased the advanced AMD susceptibility, whereas haplotypes AGAACGC, TGAACGT and TGACAGC had protective effects.
CONCLUSION
ADIPOQ genetic variant rs822396 might affect an individual's susceptibility to AMD, making it efficient genetic biomarkers for early detection of AMD.
目的
确定脂联素基因（ADIPOQ）变异与晚期年龄相关性黄斑变性（AMD）易感性之间的关系。
方法
共招募了189例晚期AMD患者和168例对照。采用SNaPshot方法对ADIPOQ中的7个标签单核苷酸多态性进行基因分型。
结果
rs822396的等位基因或基因型在晚期AMD患者和对照中的分布存在显著差异。rs822396处的次要等位基因G在显性模型中与晚期AMD风险增加相关。此外，单倍型分析显示，单倍型AGGACCT和TGACCCC显著增加了晚期AMD易感性，而单倍型AGAACGC、TGAACGT和TGACAGC具有保护作用。
结论
ADIPOQ基因变异rs822396可能影响个体对AMD的易感性，使其成为早期检测AMD的有效遗传生物标志物。
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