Du Xiubo, Wang Chao, Liu Qiong
College of Life Sciences, Shenzhen Key Laboratory of Microbial Genetic Engineering, Shenzhen University, Shenzhen 518060, China.
Curr Top Med Chem. 2016;16(8):835-48. doi: 10.2174/1568026615666150827094936.
Alzheimer's disease is a devastating and invariably fatal neurodegenerative brain disorder with no cure. AD is characterized by two pathological protein deposits, the senile plaques composed mainly of amyloid-β (Aβ) peptide and the neurofibrillary tangles which are bundles of paired helical filaments (PHF) of protein tau. In addition, oxidative stress, disorders in signal transduction and metal ions dyshomeostasis also play significant roles in the development of AD. A large body of studies suggests that selenium (Se), either as Se-containing compounds or as selenoproteins, may be beneficial in reducing Alzheimer's pathology. Se is involved in most of the molecular pathways that are important in the progression of AD. We reviewed the literature regarding Se and AD and discussed the roles and mechanisms of Se in AD, as well as the potential of Se in AD prevention.
阿尔茨海默病是一种毁灭性的、不可治愈的神经退行性脑部疾病，最终会导致死亡。阿尔茨海默病的特征是出现两种病理性蛋白质沉积物，即主要由β-淀粉样蛋白（Aβ）肽组成的老年斑和由蛋白质tau的双螺旋丝（PHF）束构成的神经原纤维缠结。此外，氧化应激、信号转导紊乱和金属离子稳态失衡在阿尔茨海默病的发展过程中也起着重要作用。大量研究表明，硒（Se）无论是以含硒化合物还是以硒蛋白的形式存在，都可能有助于减轻阿尔茨海默病的病理变化。硒参与了阿尔茨海默病进展过程中大多数重要的分子途径。我们回顾了有关硒与阿尔茨海默病的文献，并讨论了硒在阿尔茨海默病中的作用和机制，以及硒在预防阿尔茨海默病方面的潜力。
