银屑病中的CXCL10

CXCL10 in psoriasis.

作者信息

Ferrari Silvia Martina, Ruffilli Ilaria, Colaci Michele, Antonelli Alessandro, Ferri Clodoveo, Fallahi Poupak

机构信息

Department of Clinical and Experimental Medicine, University of Pisa, Pisa, Italy.

Rheumatology Unit, Medical School, University of Modena and Reggio Emilia, Azienda Ospedaliero-Universitaria, Policlinico di Modena, Modena, Italy.

出版信息

Adv Med Sci. 2015 Sep;60(2):349-54. doi: 10.1016/j.advms.2015.07.011. Epub 2015 Aug 12.

DOI:10.1016/j.advms.2015.07.011

PMID:26318079

Abstract

Chemokine (C-X-C motif) ligand (CXCL)10 is involved in the pathogenesis of psoriasis. It has been demonstrated that chemokine (C-X-C motif) receptors (CXCR)3 and CXCL10 were detected in keratinocytes and the dermal infiltrate obtained from active psoriatic plaques and that successful treatment of active plaques decreased the expression of CXCL10. Elevated CXCL10 serum levels have been shown in patients with psoriasis, with a type 1 T helper cells immune predominance at the beginning of the disease, while a decline of this chemokine has been evidenced later, in long lasting psoriasis. Circulating CXCL10 is significantly higher in patients with psoriasis in the presence of autoimmune thyroiditis. It has been hypothesized that CXCL10 could be a good marker to monitor the activity or progression of psoriasis. Efforts have been made to modulate or inhibit the CXCR3/CXCL10 axis in psoriasis to modify the course of the disease.

摘要

趋化因子（C-X-C基序）配体（CXCL）10参与银屑病的发病机制。已有研究表明，在从活动性银屑病斑块获取的角质形成细胞和真皮浸润中可检测到趋化因子（C-X-C基序）受体（CXCR）3和CXCL10，且活动性斑块的成功治疗可降低CXCL10的表达。银屑病患者血清CXCL10水平升高，在疾病初期以1型辅助性T细胞免疫为主，而在病程较长的银屑病中，该趋化因子水平随后会下降。在合并自身免疫性甲状腺炎的银屑病患者中，循环CXCL10水平显著更高。据推测，CXCL10可能是监测银屑病活动或进展的良好标志物。人们已努力在银屑病中调节或抑制CXCR3/CXCL10轴以改变疾病进程。