[1例每周使用紫杉醇作为乳腺癌新辅助化疗引发疑似光敏反应的病例]

[A Case of a Suspected Photosensitive Reaction Induced by Weekly Paclitaxel as Neoadjuvant Chemotherapy for Breast Cancer].

作者信息

Watanabe Hiroyuki, Hoshi Ikuko, Nakai Yuka, Yamasaki Keiichi, Abe Hajime

机构信息

Dept. of Pharmacy Bell Land General Hospital.

出版信息

Gan To Kagaku Ryoho. 2015 Aug;42(8):981-4.

PMID:26321713

Abstract

We report a suspected photosensitive reaction induced by weekly paclitaxel (PTX) in a patient with breast cancer. The patient was a 72-year-old woman with right breast cancer (T2N1M0, Stage II B). She received 80 mg/m² PTX weekly as neoadjuvant chemotherapy. After the 5 courses of weekly PTX, she began to develop skin lesions with itchy sensations on the areas of her body that had been exposed to sunlight. The symptoms persisted after the 6 courses of weekly PTX, and topical steroid and antihistamine treatments were initiated. The skin lesions resolved once the patient avoided sunlight and used sunscreen. Ultimately, she received 12 courses of PTX. We need to recognize the appearance of a photosensitive reaction following weekly PTX for breast cancer.

摘要

我们报告了1例乳腺癌患者在接受每周一次紫杉醇（PTX）治疗后疑似发生光敏反应的病例。该患者为一名72岁女性，患有右乳腺癌（T2N1M0，II B期）。她接受每周80mg/m²的PTX作为新辅助化疗。在接受5个周期的每周一次PTX治疗后，她身体暴露于阳光的部位开始出现伴有瘙痒感的皮肤病变。在接受6个周期的每周一次PTX治疗后症状仍持续存在，遂开始局部使用类固醇和抗组胺药治疗。一旦患者避免阳光照射并使用防晒霜，皮肤病变即消退。最终，她接受了12个周期的PTX治疗。我们需要认识到乳腺癌患者在接受每周一次PTX治疗后会出现光敏反应。