早产新生儿早期血小板计数下降的预后意义
Prognostic significance of early platelet count decline in preterm newborns.
作者信息
Elmoneim Abeer Abd, Zolaly Mohammed, El-Moneim Ehab Abd, Sultan Eisa
机构信息
Department of Pediatric, Taibah University, Almadinah Almounourah, Saudi Arabia ; Department of Pediatric, Sohag University, Sohag, Egypt.
Department of Pediatric, Taibah University, Almadinah Almounourah, Saudi Arabia.
出版信息
Indian J Crit Care Med. 2015 Aug;19(8):456-61. doi: 10.4103/0972-5229.162462.
OBJECTIVES
Decline of platelets with or without thrombocytopenia is observed in critically ill preterm newborns. Prognostic significance of platelets count in Neonatal Intensive Care Unit focused on outcome after thrombocytopenia. We aimed to estimate the changes in platelets count within the first 7 days of life in preterm newborns and its relation to final outcomes.
METHODS
Retrospectively, the platelets count during the first 7 days of life, and its association with mortality, length of stay among survivors (LOS), and later severe morbidities were determined. Appropriate regression analyses were used to examine possible relations between studied variables.
RESULTS AND DISCUSSION
Platelets drop that did not reach thrombocytopenia level in the first 7 days of life happened in 61.7%. Platelets count drop in the first 7 days of life was a predictor of mortality, LOS, and major morbidities such as intraventricular hemorrhage and necrotizing enterocolitis.
CONCLUSIONS
Platelets count drop within the first 7 days of life independent of thrombocytopenia can be used to predict increased mortality, LOS, and the development of later severe morbidities in critically ill preterm neonates.
目的
在危重新生儿中可观察到血小板减少或不伴有血小板减少的情况。新生儿重症监护病房中血小板计数的预后意义主要集中在血小板减少后的结局。我们旨在评估早产儿出生后7天内血小板计数的变化及其与最终结局的关系。
方法
回顾性分析出生后7天内的血小板计数，以及其与死亡率、存活者住院时间（LOS）和后期严重疾病的相关性。采用适当的回归分析来检验研究变量之间的可能关系。
结果与讨论
61.7%的早产儿在出生后7天内血小板下降但未达到血小板减少水平。出生后7天内血小板计数下降是死亡率、住院时间以及诸如脑室内出血和坏死性小肠结肠炎等主要疾病的预测指标。
结论
出生后7天内血小板计数下降，无论是否伴有血小板减少，均可用于预测危重新生儿死亡率增加、住院时间延长以及后期严重疾病的发生。
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