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Paradoxical Role of IL-17 in Progression of Diabetic Nephropathy.

作者信息

Galvan Daniel L, Danesh Farhad R

机构信息

Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and.

Section of Nephrology, The University of Texas MD Anderson Cancer Center, Houston, Texas; and Department of Pharmacology, Baylor College of Medicine, Houston, Texas

出版信息

J Am Soc Nephrol. 2016 Mar;27(3):657-8. doi: 10.1681/ASN.2015070813. Epub 2015 Sep 2.

Abstract
摘要

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Targeting T helper 17 by mycophenolate mofetil attenuates diabetic nephropathy progression.
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IL-17 family: cytokines, receptors and signaling.
Cytokine. 2013 Nov;64(2):477-85. doi: 10.1016/j.cyto.2013.07.022. Epub 2013 Sep 3.
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Double deficiency in IL-17 and IFN-γ signalling significantly suppresses the development of diabetes in the NOD mouse.
Diabetologia. 2013 Aug;56(8):1773-80. doi: 10.1007/s00125-013-2935-8. Epub 2013 May 23.
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Naturally transmitted segmented filamentous bacteria segregate with diabetes protection in nonobese diabetic mice.
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Distinct roles of IL-23 and IL-17 in the development of psoriasis-like lesions in a mouse model.
J Immunol. 2011 Apr 1;186(7):4481-9. doi: 10.4049/jimmunol.1000148. Epub 2011 Feb 23.
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IL-17RC is required for IL-17A- and IL-17F-dependent signaling and the pathogenesis of experimental autoimmune encephalomyelitis.
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