通过三重催化实现丙烯醇与芳基卤化物的选择性3,3-二芳基化和1,3-二芳基化的包含不同类型Heck反应的多米诺反应。
Domino Reactions Containing Different Types of Heck Reactions for Selective 3,3- and 1,3-Diarylations of Propenol with Aryl Halides by Triple Catalysis.
作者信息
Zhu Zhi-Qiang, He Jian-Shi, Wang Hai-Jun, Huang Zhi-Zhen
机构信息
Department of Chemistry, Zhejiang University , Hangzhou 310028, China.
Jiangsu Coben Pharmaceutical Co., Ltd , Qidong, Jiangsu 310004, P. R. China.
出版信息
J Org Chem. 2015 Sep 18;80(18):9354-9. doi: 10.1021/acs.joc.5b01650. Epub 2015 Sep 9.
A new domino Heck-isomerization/Saegusa/Heck reaction of propenol with aryl iodides has been developed for the synthesis of 3,3-diaryl propenals by triple transition-metal catalysis. Moreover, we also developed the domino Heck-isomerization/Heck-type reaction of propenol with aryl iodides for the synthesis of 1,3-diaryl propanones by double transition-metal catalysis and the mediation of secondary amine or triple transition metal catalysis and aminocatalysis.
已经开发出一种新的烯丙醇与芳基碘化物的多米诺 Heck 异构化/Saegusa/Heck 反应，用于通过三重过渡金属催化合成 3,3-二芳基丙烯醛。此外，我们还开发了烯丙醇与芳基碘化物的多米诺 Heck 异构化/Heck 型反应，用于通过双过渡金属催化以及仲胺介导或三重过渡金属催化和氨基催化来合成 1,3-二芳基丙酮。
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