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[Changes in biological properties of tick-borne encephalitis virus during cleavage of disulfide bonds in protein E].

作者信息

Vorovich M F, Timofeev A V, Mal'dov D G, Khaustov V I, El'bert L B

出版信息

Vopr Virusol. 1989 Nov-Dec;34(6):698-701.

PMID:2633464
Abstract

The study showed the disruption of disulphide bonds in E protein of tick-borne encephalitis virus (TBE) to lead to the loss of antigenicity, infectivity, hemagglutinating and protective activities. The loss of infectivity under the effect of a thiolic reagent appears to be associated with block of the very first stage of virus-cell interaction, virus adsorption on the target cell. An attempt to reestablish the E protein structure and the above-mentioned virus properties after the removal of the thiolic reagent failed. The role of tertiary structure of E protein in the manifestation of TBE virus main biological properties is discussed.

摘要

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