Shivappa Nitin, Sandin Sven, Löf Marie, Hébert James R, Adami Hans-Olov, Weiderpass Elisabete
Cancer Prevention and Control Program, University of South Carolina, Columbia, SC 29208, USA.
Department of Epidemiology and Biostatistics, Arnold School of Public Health, University of South Carolina, Columbia, SC 29208, USA.
Br J Cancer. 2015 Sep 29;113(7):1099-103. doi: 10.1038/bjc.2015.304. Epub 2015 Sep 3.
The role of diet in breast cancer (BrCa) aetiology has been studied widely. Although the results are inconsistent, dietary components have been implicated through their effects on inflammation. We examined the association between a dietary inflammatory index (DII) and BrCa incidence in the Swedish Women's Lifestyle Study.
The DII was computed at baseline from a validated 80-item food frequency questionnaire in a cohort of 49 258 women, among whom 1895 incident BrCa cases were identified through linkage with the National Cancer Registry through 2011. We used multivariable Cox proportional models to estimate hazard ratios (HR).
Positive associations were observed between DII and BrCa (HRDII quartile 4 vs 1=1.18; 95% CI: 1.00, 1.39), with somewhat stronger associations in postmenopausal women (HRDII quartile 4 vs 1=1.22; 95% CI: 1.01, 1.46).
A proinflammatory diet appears to increase the risk of developing BrCa, especially in postmenopausal women.
饮食在乳腺癌病因学中的作用已得到广泛研究。尽管结果并不一致，但饮食成分已因其对炎症的影响而受到牵连。我们在瑞典女性生活方式研究中考察了饮食炎症指数（DII）与乳腺癌发病率之间的关联。
根据一份经过验证的80项食物频率问卷，在49258名女性队列中于基线时计算DII，其中通过与国家癌症登记处的关联，在2011年之前确定了1895例乳腺癌新发病例。我们使用多变量Cox比例模型来估计风险比（HR）。
观察到DII与乳腺癌之间存在正相关（DII第4四分位数与第1四分位数相比，HR = 1.18；95%置信区间：1.00，1.39），在绝经后女性中关联稍强（DII第4四分位数与第1四分位数相比，HR = 1.22；95%置信区间：1.01，1.46）。
促炎饮食似乎会增加患乳腺癌的风险，尤其是在绝经后女性中。
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