AICTE National Doctoral Fellow, Institute of Pharmaceutical Sciences, Kurukshetra University, Kurukshetra, Haryana-136119, India.
Curr Drug Metab. 2015;16(4):284-93. doi: 10.2174/138920021604150902180008.
It is now very much clear that the microbiome plays an important part in human health. Microbiome is associated with several diseases and targeting the whole microbiome is certainly a challenge before the scientists. The "Human Microbiome Project" is continually exploring certain therapeutic targets inside microbiome landscape that could be utilized for the treatment of microbiome associated diseases. Additionally, associated research across the globe is going on and now some potential targets are available that might be beneficial for the designing and synthesis of novel drugs. In this review, we made an effort to discuss all the potential targets and corresponding possible drugs/treatments available for each of them. However, it is not possible to treat all microbiome associated diseases with a single drug/drug combination. Therefore, for different diseases, different treatments/drugs (whether xenobiotic or non-xenobiotic) could be used for better therapeutic efficacy.
现在非常清楚的是，微生物组在人类健康中起着重要作用。微生物组与多种疾病有关，针对整个微生物组是科学家面临的一个挑战。“人类微生物组计划”正在不断探索微生物组景观中的某些治疗靶点，这些靶点可用于治疗与微生物组相关的疾病。此外，全球范围内正在进行相关研究，现在有一些潜在的靶点可能有助于设计和合成新型药物。在这篇综述中，我们努力讨论了所有潜在的靶点以及针对它们的相应可能的药物/治疗方法。然而，不可能用单一药物/药物组合治疗所有与微生物组相关的疾病。因此，对于不同的疾病，可以使用不同的治疗方法/药物（无论是外源性的还是非外源性的）以获得更好的治疗效果。
