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严重创伤性脑损伤的减压性颅骨切除术:预后因素及并发症

Decompressive craniectomy in severe traumatic brain injury: prognostic factors and complications.

作者信息

Grille Pedro, Tommasino Nicolas

机构信息

Universidad de la Republica Uruguay, Montevidéo, Uruguay.

Instituto Nacional de Donación y Transplantes, Universidad de la Republica Uruguay, Montevidéo, Uruguay.

出版信息

Rev Bras Ter Intensiva. 2015 Apr-Jun;27(2):113-8. doi: 10.5935/0103-507X.20150021.

Abstract

OBJECTIVE

To analyze the clinical characteristics, complications and factors associated with the prognosis of severe traumatic brain injury among patients who undergo a decompressive craniectomy.

METHODS

Retrospective study of patients seen in an intensive care unit with severe traumatic brain injury in whom a decompressive craniectomy was performed between the years 2003 and 2012. Patients were followed until their discharge from the intensive care unit. Their clinical-tomographic characteristics, complications, and factors associated with prognosis (univariate and multivariate analysis) were analyzed.

RESULTS

A total of 64 patients were studied. Primary and lateral decompressive craniectomies were performed for the majority of patients. A high incidence of complications was found (78% neurological and 52% nonneurological). A total of 42 patients (66%) presented poor outcomes, and 22 (34%) had good neurological outcomes. Of the patients who survived, 61% had good neurological outcomes. In the univariate analysis, the factors significantly associated with poor neurological outcome were postdecompressive craniectomy intracranial hypertension, greater severity and worse neurological state at admission. In the multivariate analysis, only postcraniectomy intracranial hypertension was significantly associated with a poor outcome.

CONCLUSION

This study involved a very severe and difficult to manage group of patients with high morbimortality. Intracranial hypertension was a main factor of poor outcome in this population.

摘要

目的

分析接受去骨瓣减压术的重型颅脑损伤患者的临床特征、并发症及与预后相关的因素。

方法

对2003年至2012年间在重症监护病房接受去骨瓣减压术的重型颅脑损伤患者进行回顾性研究。对患者进行随访直至其从重症监护病房出院。分析其临床影像学特征、并发症及与预后相关的因素(单因素和多因素分析)。

结果

共研究了64例患者。大多数患者接受了初次和侧方去骨瓣减压术。发现并发症发生率较高(神经并发症78%,非神经并发症52%)。共有42例患者(66%)预后不良,22例(34%)神经功能预后良好。存活患者中,61%神经功能预后良好。单因素分析中,与神经功能预后不良显著相关的因素是去骨瓣减压术后颅内高压、入院时病情更严重及神经状态更差。多因素分析中,仅去骨瓣切除术后颅内高压与预后不良显著相关。

结论

本研究纳入了一组病情非常严重且难以管理、病死率高的患者。颅内高压是该人群预后不良的主要因素。

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