Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China; School of Biochemical Engineering, Anhui Polytechnic University, Wuhu 241000, China.
Key Laboratory of Food Colloids and Biotechnology, Ministry of Education, School of Chemical and Material Engineering, Jiangnan University, Wuxi 214122, China.
Carbohydr Polym. 2015 Nov 20;133:637-43. doi: 10.1016/j.carbpol.2015.07.035. Epub 2015 Jul 18.
The self-assembly of amphiphilic copolymers has attracted much attention because of their various morphologies and potential applications. Bowl-shaped nanoparticles could apply in many aspects due to their interior cavity, specific concave structure and high surface area. In this study, dextran (Dex) was hydrophobic modified by cinnamic acid (CINN) via esterification reaction between the hydroxyl group of Dex and the carboxyl group of CINN. The modification degree of CINN could be achieved by changing the feed ratios between Dex, CINN and the coupling agent. The cinnamic acid-modified dextran (Dex-CINN) composed of Dex as hydrophilic segment and CINN as hydrophobic segment could self-assemble into bowl-shaped nanoparticles with a single dimple on the surface. Furthermore, the size of the dimples could be controlled by changing the modification degree of CINN, concentration of Dex-CINN and the rate of water addition. The morphologies of bowl-shaped nanoparticles were characterized by transmission electron microscopy (TEM) and scanning electron microscope (SEM).
两亲性嵌段共聚物的自组装因其具有多种形态和潜在应用而受到广泛关注。碗状纳米粒子由于其内部空腔、特定的凹面结构和高表面积，可应用于许多方面。在这项研究中，通过葡聚糖（Dex）与肉桂酸（CINN）的羟基与羧基之间的酯化反应，将肉桂酸（CINN）对葡聚糖（Dex）进行疏水改性。CINN 的修饰程度可以通过改变 Dex、CINN 和偶联剂之间的进料比来实现。由亲水段 Dex 和疏水段 CINN 组成的肉桂酸修饰葡聚糖（Dex-CINN）可以自组装成表面有单个酒窝的碗状纳米粒子。此外，通过改变 CINN 的修饰程度、Dex-CINN 的浓度和水的加入速度，可以控制酒窝的大小。通过透射电子显微镜（TEM）和扫描电子显微镜（SEM）对碗状纳米粒子的形态进行了表征。
