感音神经性听力损失与听觉神经病谱系障碍的感知分离

Perceptual separation of sensorineural hearing loss and auditory neuropathy spectrum disorder.

作者信息

Wang Shuo, Dong Ruijuan, Liu Dongxin, Wang Yuan, Mao Yitao, Zhang Hua, Zhang Luo, Xu Li

机构信息

Otolaryngology-Head and Neck Surgery, Beijing Tongren Hospital, Beijing Institute of Otolaryngology, Capital Medical University, Beijing, People's Republic of China.

Communication Sciences and Disorders, Ohio University, Athens, Ohio, U.S.A.

出版信息

Laryngoscope. 2016 Jun;126(6):1420-5. doi: 10.1002/lary.25595. Epub 2015 Sep 7.

DOI:10.1002/lary.25595

PMID:26344821

Abstract

OBJECTIVES/HYPOTHESIS: The present study aimed to examine whether the response patterns to the chimeric lexical tone tokens, combined with their pure tone audiometry (PTA) results, could separate listeners with sensorineural hearing loss (SNHL) from listeners with auditory neuropathy spectrum disorder (ANSD).

STUDY DESIGN

Case-control study.

METHODS

Forty-three SNHL subjects and 46 ANSD subjects participated in a Mandarin lexical tone perception test using original and chimeric tone tokens. Ten sets of monosyllables, with four tone patterns for each, were processed through a 16-channel chimeric synthesizer in which a temporal envelope (E) from a monosyllabic word of one tone was paired with a fine structure (FS) from the same monosyllable of other tones.

RESULTS

Significantly negative correlations were present between tone perception scores and PTA0.5-4 kHz for both SNHL (P < 0.001) and ANSD (P < 0.001) subjects. Overall, 72.4%, 66.4%, and 46.3% of the tone responses were consistent with FS for the SNHL subjects with mild, moderate, and severe degree of hearing loss, respectively; and 28.4%, 23.1%, and 22.7% were consistent with FS for the ANSD subjects, with the equivalent degree of hearing loss. Similarly, 17.6%, 24.2%, and 37.7% of the tone responses were consistent with E for the SNHL subjects with mild, moderate, and severe degree of hearing loss, respectively; and 45.5%, 44.3%, and 36.5% were consistent with E for the ANSD subjects.

CONCLUSION

Subjects with SNHL and ANSD may be separated by representing their FS- and E-consistent tone responses as a function of their pure-tone hearing thresholds.

LEVEL OF EVIDENCE

3b. Laryngoscope, 126:1420-1425, 2016.

摘要

目的/假设：本研究旨在探讨对嵌合声调刺激的反应模式，结合其纯音听力测定（PTA）结果，能否将感音神经性听力损失（SNHL）的受试者与听神经病谱系障碍（ANSD）的受试者区分开来。

研究设计

病例对照研究。

方法

43名SNHL受试者和46名ANSD受试者参加了一项使用原始声调刺激和嵌合声调刺激的汉语声调感知测试。十组单音节词，每组有四种声调模式，通过一个16通道的嵌合合成器进行处理，其中一个声调的单音节词的时间包络（E）与其他声调的同一单音节词的精细结构（FS）配对。

结果

SNHL受试者（P < 0.001）和ANSD受试者（P < 0.001）的声调感知分数与0.5 - 4 kHz的PTA之间均存在显著负相关。总体而言，轻度、中度和重度听力损失的SNHL受试者，分别有72.4%、66.4%和46.3%的声调反应与FS一致；听力损失程度相当的ANSD受试者中，这一比例分别为28.4%、23.1%和22.7%。同样，轻度、中度和重度听力损失的SNHL受试者，分别有17.6%、24.2%和37.7%的声调反应与E一致；ANSD受试者中，这一比例分别为45.5%、44.3%和36.5%。