第1组固有淋巴细胞亚群的分化与多样性
Differentiation and diversity of subsets in group 1 innate lymphoid cells.
作者信息
Seillet Cyril, Belz Gabrielle T
机构信息
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia.
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, Melbourne, Victoria 3052, Australia Department of Medical Biology, University of Melbourne, Melbourne, Victoria 3010, Australia
出版信息
Int Immunol. 2016 Jan;28(1):3-11. doi: 10.1093/intimm/dxv051. Epub 2015 Sep 7.
NK cells were first identified in 1975 and represent the prototypical group 1 innate lymphoid cell (ILC). More recently, the discovery of new members of the ILC family has highlighted the complexity of this innate lymphoid lineage. Importantly, it has been recognized that different subsets exist within the group 1 ILC, which have potential roles in mediating immune protection and immunosurveillance, and in regulating tissue homeostasis and inflammation. Here, we review the developmental relationships between the different group 1 ILC, which have been identified to date and discuss how heterogeneity within this expanding family may have arisen.
自然杀伤细胞（NK细胞）于1975年首次被发现，是1型固有淋巴细胞（ILC）的典型代表。最近，ILC家族新成员的发现凸显了这个固有淋巴细胞谱系的复杂性。重要的是，人们已经认识到1型ILC中存在不同的亚群，它们在介导免疫保护和免疫监视、调节组织稳态和炎症方面具有潜在作用。在这里，我们回顾了迄今为止已确定的不同1型ILC之间的发育关系，并讨论了这个不断扩大的家族中的异质性可能是如何产生的。
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