Figueroa R G, Valente M
Universidad de La Frontera, Francisco Salazar 1145, Temuco, IX Región, Chile.
Phys Med Biol. 2015 Sep 21;60(18):7191-206. doi: 10.1088/0031-9155/60/18/7191. Epub 2015 Sep 8.
The main purpose of this work is to determine the feasibility and physical characteristics of a new teletherapy device of radiation therapy based on the application of a convergent x-ray beam of energies like those used in radiotherapy providing highly concentrated dose delivery to the target. We have denominated it Convergent Beam Radio Therapy (CBRT). Analytical methods are developed first in order to determine the dosimetry characteristic of an ideal convergent photon beam in a hypothetical water phantom. Then, using the PENELOPE Monte Carlo code, a similar convergent beam that is applied to the water phantom is compared with that of the analytical method. The CBRT device (Converay(®)) is designed to adapt to the head of LINACs. The converging beam photon effect is achieved thanks to the perpendicular impact of LINAC electrons on a large thin spherical cap target where Bremsstrahlung is generated (high-energy x-rays). This way, the electrons impact upon various points of the cap (CBRT condition), aimed at the focal point. With the X radiation (Bremsstrahlung) directed forward, a system of movable collimators emits many beams from the output that make a virtually definitive convergent beam. Other Monte Carlo simulations are performed using realistic conditions. The simulations are performed for a thin target in the shape of a large, thin, spherical cap, with an r radius of around 10-30 cm and a curvature radius of approximately 70 to 100 cm, and a cubed water phantom centered in the focal point of the cap. All the interaction mechanisms of the Bremsstrahlung radiation with the phantom are taken into consideration for different energies and cap thicknesses. Also, the magnitudes of the electric and/or magnetic fields, which are necessary to divert clinical-use electron beams (0.1 to 20 MeV), are determined using electromagnetism equations with relativistic corrections. This way the above-mentioned beam is manipulated and guided for its perpendicular impact upon the spherical cap. The first results that were achieved show in-depth dose peaks, having shapes qualitatively similar to those from hadrontherapy techniques. The obtained results demonstrate that in-depth dose peaks are generated at the focus point or isocenter. These results are consistent with those obtained with Monte Carlo codes. The peak-focus is independent of the energy of the photon beam, though its intensity is not. The realistic results achieved with the Monte Carlo code show that the Bremsstrahlung generated on the thin cap is mainly directed towards the focus point. The aperture angle at each impact point depends primarily on the energy beam, the atomic number Z and the thickness of the target. There is also a poly-collimator coaxial to the cap or ring with many holes, permitting a clean convergent-exit x-ray beam with a dose distribution that is similar to the ideal case. The electric and magnetic fields needed to control the deflection of the electron beams in the CBRT geometry are highly feasible using specially designed electric and/or magnetic devices that, respectively, have voltage and current values that are technically achievable. However, it was found that magnetic devices represent a more suitable option for electron beam control, especially at high energies. The main conclusion is that the development of such a device is feasible. Due to its features, this technology might be considered a powerful new tool for external radiotherapy with photons.
这项工作的主要目的是确定一种新型放射治疗远距治疗设备的可行性和物理特性,该设备基于应用能量类似于放射治疗中使用的会聚X射线束,可向靶区提供高度集中的剂量。我们将其命名为会聚束放射治疗(CBRT)。首先开发分析方法,以确定假设水模体中理想会聚光子束的剂量学特性。然后,使用PENELOPE蒙特卡罗代码,将应用于水模体的类似会聚束与分析方法的结果进行比较。CBRT设备(Converay(®))设计为可适配直线加速器的头部。由于直线加速器电子垂直撞击大型薄球冠靶产生轫致辐射(高能X射线),从而实现会聚束光子效应。这样,电子撞击球冠的不同点(CBRT条件),目标是焦点。随着X辐射(轫致辐射)向前发射,一个可移动准直器系统从输出端发射出许多束光,形成一个几乎确定的会聚束。使用实际条件进行其他蒙特卡罗模拟。模拟针对大型薄球冠形状的薄靶进行,其半径r约为10 - 30厘米,曲率半径约为70至100厘米,以及一个以球冠焦点为中心的立方体水模体。考虑了不同能量和球冠厚度下轫致辐射与模体的所有相互作用机制。此外,使用带有相对论修正的电磁方程确定使临床使用的电子束(0.1至20 MeV)偏转所需的电场和/或磁场强度。通过这种方式对上述束进行操纵和引导,使其垂直撞击球冠。取得的初步结果显示出深度剂量峰值,其形状在定性上与强子治疗技术的峰值相似。获得的结果表明,在焦点或等中心处产生深度剂量峰值。这些结果与蒙特卡罗代码获得的结果一致。峰值焦点与光子束能量无关,但其强度并非如此。蒙特卡罗代码获得的实际结果表明,薄球冠上产生的轫致辐射主要指向焦点。每个撞击点的孔径角主要取决于能量束、原子序数Z和靶的厚度。还有一个与球冠或环同轴的多孔准直器,可产生干净的会聚出射X射线束,其剂量分布类似于理想情况。使用专门设计的电场和/或磁场装置来控制CBRT几何结构中电子束的偏转所需的电场和磁场在技术上是高度可行的,这些装置分别具有技术上可实现的电压和电流值。然而,发现磁场装置是控制电子束的更合适选择,特别是在高能量时。主要结论是开发这样一种设备是可行的。由于其特性,该技术可能被视为光子外照射放射治疗的一种强大新工具。