阿巴西普引起的银屑病样药疹：STAT信号通路的免疫组织化学研究

Psoriasiform Drug Eruption Caused by Abatacept: Immunohistochemical Investigation of STAT Signaling.

作者信息

Tanita Kayo, Fujimura Taku, Kakizaki Aya, Furudate Sadanori, Kusakari Yoshiyuki, Aiba Setsuya

机构信息

Department of Dermatology, Tohoku University Graduate School of Medicine, Sendai, Japan.

出版信息

Case Rep Dermatol. 2015 Jul 24;7(2):166-70. doi: 10.1159/000437415. eCollection 2015 May-Aug.

DOI:10.1159/000437415

PMID:26351425

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4560327/

Abstract

Abatacept is a biological immune modifier that is used for the treatment of rheumatoid arthritis. Although psoriasiform drug eruption is reported as one of the cutaneous adverse effects of abatacept, the precise mechanisms are not fully understood. In this report, we describe a 65-year-old Japanese man with psoriasiform drug eruption caused by abatacept. Interestingly, immunohistochemical staining revealed that the epidermal keratinocytes in the basal layer and lower layers of the stratum spinosum were positive for pSTAT3, partially positive for pSTAT1 and negative for pSTAT6, which is similar to conventional psoriasis vulgaris. Our present study suggests that psoriasiform drug eruption caused by abatacept might develop by similar immunological mechanisms as those of psoriasis vulgaris.

摘要

阿巴西普是一种生物免疫调节剂，用于治疗类风湿性关节炎。虽然银屑病样药疹被报道为阿巴西普的皮肤不良反应之一，但其确切机制尚未完全明确。在本报告中，我们描述了一名65岁的日本男性，他因阿巴西普引发了银屑病样药疹。有趣的是，免疫组化染色显示，基底层和棘层下层的表皮角质形成细胞pSTAT3呈阳性，pSTAT1部分呈阳性，pSTAT6呈阴性，这与寻常型银屑病相似。我们目前的研究表明，阿巴西普引起的银屑病样药疹可能通过与寻常型银屑病相似的免疫机制发展而来。