局部用缬更昔洛韦治疗高血压性前葡萄膜炎。

Topical Valganciclovir for the Treatment of Hypertensive Anterior Uveitis.

作者信息

Delwig Anton, Keenan Jeremy D, Margolis Todd P

机构信息

*Department of Ophthalmology, University of California, San Francisco, San Francisco, CA; and †Francis I. Proctor Foundation, University of California, San Francisco, San Francisco, CA; A. Delwig is now with SiteOne Therapeutics, San Francisco, CA; and T. P. Margolis is now with the Department of Ophthalmology, Washington University, Saint Louis, MO.

出版信息

Cornea. 2015 Nov;34(11):1513-5. doi: 10.1097/ICO.0000000000000579.

DOI:10.1097/ICO.0000000000000579

PMID:26356754

Abstract

PURPOSE

To report the use of topical valganciclovir for the treatment of hypertensive anterior uveitis associated with clinical signs of cytomegalovirus (CMV) iritis.

METHODS

A case report and review of the literature.

RESULTS

A 37-year-old man was referred with a unilateral hypertensive anterior uveitis with keratic precipitates suggestive of CMV as the causative agent. After institution of oral valganciclovir and topical corticosteroids, the patient's ocular inflammation resolved and intraocular pressure normalized. Therapy was eventually changed from oral valganciclovir to ophthalmic 1% valganciclovir ointment, which was able to effectively control ocular inflammation and allow the patient to discontinue topical corticosteroids and antihypertensive medications. Topical application of valganciclovir did not result in clinically evident ocular surface toxicity.

CONCLUSIONS

1% valganciclovir ointment may prove to be an effective treatment of hypertensive anterior uveitis associated with clinical signs of CMV iritis.

摘要

目的

报告局部应用缬更昔洛韦治疗伴有巨细胞病毒（CMV）虹膜炎临床体征的高血压性前葡萄膜炎。

方法

病例报告及文献复习。

结果

一名37岁男性因单侧高血压性前葡萄膜炎伴角膜后沉着物就诊，提示CMV为病原体。口服缬更昔洛韦和局部应用糖皮质激素后，患者眼部炎症消退，眼压恢复正常。治疗最终从口服缬更昔洛韦改为局部应用1%缬更昔洛韦眼膏，其能够有效控制眼部炎症，使患者停用局部糖皮质激素和抗高血压药物。局部应用缬更昔洛韦未导致明显的眼表毒性。