Department of Clinical Immunology, Saint-Louis Hospital, Assistance Publique des Hopitaux de Paris, Paris, France; Institut National de la Sante et de la Recherche Medicale (INSERM) Unite Mixte de Recherche (UMR)_1126, Institut Universitaire d'Hematologie, Universite Paris 7 Denis Diderot, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
Department of Dermatology, Saint-Louis Hospital, Paris, France; Groupe d'Etude des Dermatoses associées à une Immunoglobuline Monoclonale, Paris, France.
J Am Acad Dermatol. 2015 Nov;73(5):809-20. doi: 10.1016/j.jaad.2015.07.031. Epub 2015 Sep 11.
Neutrophilic dermatoses refer to a group of cutaneous inflammatory disorders characterized by neutrophilic infiltration of the skin. Neutrophilic dermatoses have been reported in association with various conditions including autoimmune diseases, inflammatory bowel diseases, and neoplasia. In the later condition, myeloproliferative disorders and monoclonal gammopathy (monoclonal immunoglobulin [MIg]) are the most frequent. Only few data are available in case of neutrophilic dermatoses associated with MIg regarding the pathophysiology and the clinical outcome.
We sought to gain further insight into clinical and biological aspects of neutrophilic dermatoses associated with MIg.
We report a retrospective series of 26 patients with neutrophilic dermatoses associated with MIg focusing on clinical and biological aspects, with a study of a large panel of cytokines, chemokines, and adhesion molecules.
This study reveals an association between MIg IgA isotype and neutrophilic dermatoses, and a specific inflammatory pattern including elevated interleukin 6, vascular endothelial growth factor, monocyte chemotactic protein-1, epidermal growth factor, and intercellular adhesion molecule-1.
This is a retrospective study from a single institution with a limited number of participants.
Our data highlight a strong association between IgA isotype and neutrophilic dermatoses, and the existence of a specific inflammatory profile involving several molecules.
中性粒细胞皮肤病是一组以皮肤中性粒细胞浸润为特征的皮肤炎症性疾病。中性粒细胞皮肤病与多种疾病有关，包括自身免疫性疾病、炎症性肠病和肿瘤。在后一种情况下，骨髓增生性疾病和单克隆丙种球蛋白病（单克隆免疫球蛋白[MIg]）最为常见。关于与 MIg 相关的中性粒细胞皮肤病的发病机制和临床结果，仅有少量数据。
我们旨在进一步了解与 MIg 相关的中性粒细胞皮肤病的临床和生物学方面。
我们报告了 26 例与 MIg 相关的中性粒细胞皮肤病的回顾性系列研究，重点关注临床和生物学方面，并研究了大量细胞因子、趋化因子和黏附分子。
本研究揭示了 MIg IgA 同种型与中性粒细胞皮肤病之间的关联，以及包括白细胞介素 6、血管内皮生长因子、单核细胞趋化蛋白-1、表皮生长因子和细胞间黏附分子-1 在内的特定炎症模式。
这是一项来自单一机构的回顾性研究，参与者数量有限。
我们的数据强调了 IgA 同种型与中性粒细胞皮肤病之间的强烈关联，以及涉及多种分子的特定炎症特征。
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