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癌症治疗后的乳房重建。

Breast Reconstruction Following Cancer Treatment.

作者信息

Gerber Bernd, Marx Mario, Untch Michael, Faridi Andree

机构信息

Department of Obstetrics and Gynecology, University of Rostock, Clinic for Plastic Surgery, Radebeul, Helios Klinikum Berlin Buch, Center for Breast Diseases, Vivantes Hospital am Urban, Berlin.

出版信息

Dtsch Arztebl Int. 2015 Aug 31;112(35-36):593-600. doi: 10.3238/arztebl.2015.0593.

Abstract

BACKGROUND

About 8000 breast reconstructions after mastectomy are per - formed in Germany each year. It has become more difficult to advise patients because of the wide variety of heterologous and autologous techniques that are now available and because of changes in the recommendations about radiotherapy.

METHODS

This article is based on a review of pertinent articles (2005-2014) that were retrieved by a selective search employing the search terms "mastectomy" and "breast reconstruction."

RESULTS

The goal of reconstruction is to achieve an oncologically safe and aestically satisfactory result for the patient over the long term. Heterologous, i.e., implant-based, breast reconstruction (IBR) and autologous breast reconstruction (ABR) are complementary techniques. Immediate reconstruction preserves the skin of the breast and its natural form and prevents the psychological trauma associated with mastectomy. If post-mastectomy radiotherapy (PMRT) is not indicated, implant-based reconstruction with or without a net/acellular dermal matrix (ADM) is a common option. Complications such as seroma formation, infection, and explantation are significantly more common when an ADM is used (15.3% vs. 5.4% ). If PMRT is performed, then the complication rate of implant-based breast reconstruction is 1 to 48% ; in particular, Baker grade III/IV capsular fibrosis occurs in 7 to 22% of patients, and the prosthesis must be explanted in 9 to 41% . Primary or, preferably, secondary autologous reconstruction is an alternative. The results of ABR are more stable over the long term, but the operation is markedly more complex. Autologous breast reconstruction after PMRT does not increase the risk of serious complications (20.5% vs. 17.9% without radiotherapy).

CONCLUSION

No randomized controlled trials have yet been conducted to compare the reconstructive techniques with each other. If radiotherapy will not be performed, immediate reconstruction with an implant is recommended. On the other hand, if post-mastectomy radiotherapy is indicated, then secondary autologous breast reconstruction is the procedure of choice. Future studies should address patients' quality of life and the long-term aesthetic results after breast reconstruction.

摘要

背景

在德国,每年约有8000例乳房切除术后的乳房重建手术。由于目前可用的多种异体和自体技术,以及放疗建议的变化,为患者提供建议变得更加困难。

方法

本文基于对相关文章(2005 - 2014年)的综述,这些文章通过使用搜索词“乳房切除术”和“乳房重建”进行选择性检索获得。

结果

重建的目标是为患者长期实现肿瘤学上安全且美学上令人满意的结果。异体即基于植入物的乳房重建(IBR)和自体乳房重建(ABR)是互补技术。即刻重建保留了乳房皮肤及其自然形态,并防止了与乳房切除术相关的心理创伤。如果不进行乳房切除术后放疗(PMRT),使用或不使用网片/脱细胞真皮基质(ADM)的基于植入物的重建是一种常见选择。使用ADM时,血清肿形成、感染和取出植入物等并发症明显更常见(15.3%对5.4%)。如果进行PMRT,基于植入物的乳房重建的并发症发生率为1%至48%;特别是,7%至22%的患者会出现贝克III/IV级包膜纤维化,9%至41%的患者必须取出假体。一期或更优选二期自体重建是一种替代方案。ABR的长期结果更稳定,但手术明显更复杂。PMRT后的自体乳房重建不会增加严重并发症的风险(20.5%对未放疗时的17.9%)。

结论

尚未进行随机对照试验来相互比较重建技术。如果不进行放疗,建议即刻植入物重建。另一方面,如果需要进行乳房切除术后放疗,那么二期自体乳房重建是首选方法。未来的研究应关注乳房重建后患者的生活质量和长期美学效果。

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