Institutionen för Medicinska Vetenskaper, Uppsala Universitet, Uppsala, Sweden.
Cardiovascular Division, Brigham and Women's Hospital, Harvard Medical School, Boston, Massachusetts.
JACC Cardiovasc Imaging. 2015 Sep;8(9):1071-1093. doi: 10.1016/j.jcmg.2015.07.004.
Left ventricular diastolic dysfunction in clinical practice is generally diagnosed by imaging. Recognition of heart failure with preserved ejection fraction has increased interest in the detection and evaluation of this condition and prompted an improved understanding of the strengths and weaknesses of different imaging modalities for evaluating diastolic dysfunction. This review briefly provides the pathophysiological background for current clinical and experimental imaging parameters of diastolic dysfunction, discusses the merits of echocardiography relative to other imaging modalities in diagnosing and grading diastolic dysfunction, summarizes lessons from clinical trials that used parameters of diastolic function as an inclusion criterion or endpoint, and indicates current areas of research.
在临床实践中,左心室舒张功能障碍通常通过影像学诊断。对射血分数保留型心力衰竭的认识增加了对这种情况的检测和评估的兴趣,并促使人们更好地理解不同影像学方法评估舒张功能障碍的优缺点。这篇综述简要介绍了目前临床和实验性舒张功能障碍影像学参数的病理生理学背景,讨论了超声心动图相对于其他影像学方法在诊断和分级舒张功能障碍方面的优点,总结了将舒张功能参数作为入选标准或终点的临床试验的经验教训,并指出了当前的研究领域。