未经治疗的虹膜黑色素瘤并发前房积血及对碘-125近距离放射治疗有反应的难治性青光眼。
UNTREATED IRIS MELANOMA COMPLICATED BY HYPHEMA AND UNCONTROLLED GLAUCOMA RESPONSIVE TO IODINE-125 BRACHYTHERAPY.
作者信息
Chang Melinda Y, McCannel Colin A, McCannel Tara A
机构信息
*Department of Ophthalmology, Ophthalmic Oncology Center, Stein Eye Institute, University of California, Los Angeles, California; and †The Stein Eye Institute, University of California, Los Angeles, California.
出版信息
Retin Cases Brief Rep. 2016 Winter;10(1):44-7. doi: 10.1097/ICB.0000000000000171.
PURPOSE
To describe a case of iris melanoma for which a patient refused treatment for 15 years, and the complications that resulted.
METHODS
Single case report.
RESULTS
A 52-year-old white man was evaluated for a suspicious pigmented lesion of the left iris. He was followed closely with serial examinations and ultrasound biomicroscopy, and he refused therapy when the lesion showed growth 15 years after presentation. The patient subsequently developed recurrent hyphema, intraocular pressure up to 55 mmHg, and glaucomatous optic neuropathy. He eventually underwent iodine-125 brachytherapy resulting in tumor regression and improvement of intraocular pressure.
CONCLUSION
Untreated iris melanoma can develop complications such as recurrent hyphema and glaucoma with irreversible optic nerve damage. Treatment of slow-growing iris melanoma must be considered to prevent complications.
目的
描述一例虹膜黑色素瘤患者拒绝治疗15年及其引发的并发症。
方法
单病例报告。
结果
一名52岁白人男性因左眼虹膜可疑色素沉着病变接受评估。通过系列检查和超声生物显微镜检查对其进行密切随访，病变出现15年后显示生长时，他拒绝治疗。该患者随后出现反复前房积血、眼压高达55 mmHg以及青光眼性视神经病变。他最终接受了碘-125近距离放射治疗，导致肿瘤消退和眼压改善。
结论
未经治疗的虹膜黑色素瘤可引发反复前房积血和青光眼等并发症，并伴有不可逆的视神经损伤。必须考虑对生长缓慢的虹膜黑色素瘤进行治疗以预防并发症。
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