强迫游泳试验中的不动状态是适应性的，并不反映抑郁。
Immobility in the forced swim test is adaptive and does not reflect depression.
作者信息
Molendijk Marc L, de Kloet E Ronald
机构信息
Institute of Psychology, Leiden University and Leiden Institute for Brain and Cognition, Leiden University Medical Center, Leiden, The Netherlands.
Department of Endocrinology and Metabolic Disease, Leiden University Medical Center, Leiden, The Netherlands.
出版信息
Psychoneuroendocrinology. 2015 Dec;62:389-91. doi: 10.1016/j.psyneuen.2015.08.028. Epub 2015 Sep 2.
The forced swim test is based on the progressive immobility a rodent displays when immersed in a beaker filled with water from where no escape is possible. While the test was originally designed to identify the antidepressant potential of drugs, over the past decade a rapidly growing number of publications (more than 2000) portray this immobility response anthropomorphically as a measure for depression and despair. This is incorrect. The response to the forced swim stressor should be considered for what it shows: a switch from active to passive behavior in the face of an acute stressor, aligned to cognitive functions underlying behavioral adaptation and survival.
强迫游泳试验是基于啮齿动物被浸入一个装满水且无法逃脱的烧杯中时所表现出的逐渐不动状态。虽然该试验最初旨在确定药物的抗抑郁潜力，但在过去十年中，越来越多（超过2000篇）的出版物将这种不动反应拟人化为衡量抑郁和绝望的指标。这是不正确的。对强迫游泳应激源的反应应根据其所示内容来考虑：面对急性应激源时从主动行为向被动行为的转变，这与行为适应和生存所依据的认知功能相一致。
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