Fink Anne, Doblhammer Gabriele
German Center for Neurodegenerative Diseases (DZNE) Bonn, Bonn, Germany.
Rostock Center for the Study of Demographic Change, Rostock, Germany.
J Alzheimers Dis. 2015;47(2):443-52. doi: 10.3233/JAD-142082.
As the population ages, the numbers of people developing care- and cost-intensive forms of dementia are raising. We investigated the pathways of incident dementia patients to long-term care (LTC) dependence and death, and examined the effects of: (1) the type of the main treating physician, differentiated by neurologists/psychiatrists (NPs) and non-NPs; (2) the prescription of antidementive drugs on the risk of needing LTC, differentiated by the degree of care need. Longitudinal claims data of the largest German public sickness fund of 10,043 incident dementia cases aged 60 years and above were analyzed for the years 2006 to 2010. Cox proportional hazard models were performed to investigate the risk of LTC and death based on what type of physician was treating the patient, and whether the patient was prescribed antidementive drugs; adjusted for age, gender, cardiovascular comorbidities, and the previous LTC level. The patients who were primarily treated by NPs had a significantly lower risk of LTC than patients who were mainly treated by non-NPs (considerable LTC: RR = 0.72, p = 0.000, severe LTC: RR = 0.78, p = 0.000, extreme LTC: RR = 0.67, p = 0.001). They generally had a lower risk of death. Antidementive drug treatment was correlated with an increased risk of LTC (considerable LTC: RR = 1.66, p = 0.000, severe LTC: RR = 1.50, p = 0.000, extreme LTC: RR = 1.48, p = 0.000) but with a decreased risk of death. A higher rate of involvement of specialists in the treatment of dementia patients is associated with a reduced LTC dependence and increased survival of dementia patients. Antidementive drug treatments appear to extend live years with dementia.
随着人口老龄化,患护理和费用高昂型痴呆症的人数正在增加。我们调查了新发痴呆症患者走向长期护理(LTC)依赖和死亡的途径,并研究了以下因素的影响:(1)主要治疗医生的类型,分为神经科医生/精神科医生(NPs)和非NPs;(2)抗痴呆药物处方对根据护理需求程度划分的需要长期护理风险的影响。对德国最大的公共疾病基金在2006年至2010年期间的10043例60岁及以上新发痴呆症病例的纵向理赔数据进行了分析。采用Cox比例风险模型,根据治疗患者的医生类型以及患者是否被开具抗痴呆药物来研究长期护理和死亡风险;并对年龄、性别、心血管合并症和先前的长期护理水平进行了调整。主要由NPs治疗的患者比主要由非NPs治疗的患者有显著更低的长期护理风险(相当程度的长期护理:RR = 0.72,p = 0.000;严重长期护理:RR = 0.78,p = 0.000;极度长期护理:RR = 0.67,p = 0.001)。他们总体上有更低的死亡风险。抗痴呆药物治疗与长期护理风险增加相关(相当程度的长期护理:RR = 1.66,p = 0.000;严重长期护理:RR = 1.50,p = 0.000;极度长期护理:RR = 1.48,p = 0.000),但与死亡风险降低相关。专科医生在痴呆症患者治疗中的更高参与率与痴呆症患者长期护理依赖的降低和生存率的提高相关。抗痴呆药物治疗似乎能延长痴呆症患者的存活年限。