18F-FDG PET-CT 用于检测急性髓系白血病的活动疾病。

Use of 18F-FDG PET-CT for Detection of Active Disease in Acute Myeloid Leukemia.

机构信息

From the *Departments of Radiology and Nuclear Medicine at the University of Washington, and †Department of Radiology at Seattle Children's Hospital, Seattle, WA.

出版信息

Clin Nucl Med. 2016 Mar;41(3):e137-40. doi: 10.1097/RLU.0000000000000999.

DOI:10.1097/RLU.0000000000000999

PMID:26402136

Abstract

A 4-year-old girl with history of acute myeloid leukemia post chemotherapy and stem cell transplant presented with pancytopenia. F-FDG PET-CT (PET-CT) showed multiple metastatic bone and extra medullary soft tissue lesions. Bone marrow biopsy after additional chemotherapy was negative. Concurrent FDG PET-CT demonstrated hypermetabolic foci in the left thigh and hand consistent with residual soft tissue disease. These lesions resolved after further treatment, but a subsequent PET-CT identified a new site of biopsy-proven chloroma. This case illustrates the important role of FDG PET-CT in identifying clinically undetectable extramedullary sites of disease, which may impact subsequent clinical management.

摘要

一位 4 岁女孩，曾患有急性髓系白血病，接受化疗和干细胞移植后，出现全血细胞减少。18F-FDG PET-CT（PET-CT）显示多处转移性骨和骨髓外软组织病变。在追加化疗后进行的骨髓活检呈阴性。同期 FDG PET-CT 显示左大腿和左手的高代谢病灶，符合残留软组织疾病。这些病灶在进一步治疗后得到缓解，但随后的 PET-CT 发现新的活检证实的绿色瘤部位。该病例说明了 18F-FDG PET-CT 在识别临床无法检测的骨髓外疾病部位方面的重要作用，这可能会影响后续的临床管理。