[Pseudo-pheochromocytoma due to iproniazid: A case report].
作者信息
Tréhout M, Fedrizzi S, Loggia G, Lecardeur L, Nathou C, Dollfus S
机构信息
Service de psychiatrie, centre Esquirol, CHU de Caen, 14000 Caen, France; CNRS, UMR 6301, imagerie et stratégies thérapeutiques des pathologies cérébrales et tumorales (ISTCT), équipe imagerie et stratégies thérapeutiques de la schizophrénie (ISTS), GIP CYCERON, boulevard Henri-Becquerel, 14074 Caen cedex, France.
Centre régional de pharmacovigilance de Caen Basse-Normandie, CHU de Caen, 14000 Caen, France; UFR de médecine, université de Caen Basse-Normandie, Caen, 14000 France.
出版信息
Rev Med Interne. 2016 Feb;37(2):135-8. doi: 10.1016/j.revmed.2015.07.004. Epub 2015 Sep 26.
INTRODUCTION
Pheochromocytoma is suggested by the presence of severe and paroxysmal hypertension associated with hyperadrenergy clinical signs. If the diagnosis of pheochromocytoma is ruled out, a pseudo-pheochromocytoma should be considered. We report a clinical observation of pseudo-pheochromocytoma due to iproniazid, a non-selective irreversible monoamine oxidase (MAO) A and B inhibitor in a patient with bipolar disorder.
CASE REPORT
A 78-year-old Caucasian male patient treated by iproniazid was hospitalized for depressive relapse. After several episodes of syncopes related to orthostatic hypotension, the patient presented hypertensive crisis. Urinary normetanephrines were increased to twice the upper limit of the normal range. Iproniazid was discontinued. Patient hemodynamic was rapidly stabilized and sympathetic hypertonia diminished. The urinary measurements normalized within two months. The abdominal imaging eliminated an adrenal tumor.
CONCLUSION
Iproniazid could be responsible for severe irregular blood pressure associated with abnormal catecholamine metabolism (i.e. pseudo-pheochromocytoma).
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