Pomeraniec Isaac Jonathan, Ksendzovsky Alexander, Yu Pearl L, Jane John A
Department of Neurological Surgery, University of Virginia Health Science Center, 1215 Lee Street, Charlottesville, VA 22908, USA.
Department of Neurological Surgery, University of Virginia Health Science Center, 1215 Lee Street, Charlottesville, VA 22908, USA.
Neurosurg Clin N Am. 2015 Oct;26(4):543-53. doi: 10.1016/j.nec.2015.06.009. Epub 2015 Aug 4.
Sleep apnea represents a relative indication for posterior fossa decompression in pediatric patients with Chiari malformation type 1. Duraplasty was associated with improvement of sleep apnea in 100% of patients and dural splitting with improvement in 50% of patients. Duraplasty and dural splitting were associated with a similar reduction in tonsillar herniation on radiographic imaging of 58% (37% excluding tonsillectomy) and 35%, respectively. Longitudinal follow-up studies of patients with either neurologic deficits or severe symptoms will further elucidate the natural history of Chiari malformation type 1 and more appropriately gauge the risk-benefit tradeoff of surgical intervention.
睡眠呼吸暂停是1型Chiari畸形小儿患者后颅窝减压的相对指征。硬脑膜成形术使100%的患者睡眠呼吸暂停得到改善,硬脑膜切开术使50%的患者睡眠呼吸暂停得到改善。硬脑膜成形术和硬脑膜切开术在影像学上使扁桃体疝分别减少了58%(不包括扁桃体切除术为37%)和35%,二者减少程度相似。对有神经功能缺损或严重症状患者的纵向随访研究将进一步阐明1型Chiari畸形的自然病史,并更恰当地评估手术干预的风险效益比。