[ADRA2A和ADRB3基因与鞑靼人代谢综合征的遗传关联]

[Genetic Association of ADRA2A and ADRB3 Genes with Metabolic Syndrome among the Tatars].

作者信息

Kochetova O V, Viktorova T V, Mustafina O E, Karpov A A, Khusnutdinova E K

出版信息

Genetika. 2015 Jul;51(7):830-4.

Abstract

An association study was performed for genetic polymorphisms in ADRB3 (rs4994) and ADRA2A (rs1800544, rs553668) genes to estimate their effect on quantitative parameters, including glucose, insulin, and HOMA-IR index in women from the Tatar population of Russia. It has been shown that CT and CC are associated with metabolic syndrome and increased insulin. It was shown that ADRA2A (rs1800544) gene polymorphism was associated with high levels of insulin and an increased HOMA-IR index in GG- and GC-genotype carriers.

摘要

对俄罗斯鞑靼族女性的ADRB3（rs4994）和ADRA2A（rs1800544、rs553668）基因中的遗传多态性进行了关联研究，以评估它们评估其对包括葡萄糖、胰岛素和HOMA-IR指数在内的定量参数的影响。研究表明，CT和CC与代谢综合征及胰岛素升高有关。结果显示，ADRA2A（rs1800544）基因多态性与GG和GC基因型携带者的高胰岛素水平及升高的HOMA-IR指数相关。