氯化甲基汞对猪血小板超氧化物歧化酶活性的体外作用。
The in vitro effect of methylmercuric chloride on superoxide dismutase activity of pig platelets.
作者信息
Kostka B, Krajewska U, Lipecka K
机构信息
Department of Biochemistry, Medical Academy, Lódź, Poland.
出版信息
Pol J Pharmacol Pharm. 1989 Sep-Oct;41(5):453-8.
PMID:2641398
Abstract
Incubation of the suspension of washed pig platelets with methylmercuric chloride (MeHg) caused decrease of superoxide dismutase (SOD) activity at the concentrations of MeHg 10(-5)-10(-4) mol/l. We also observed the increase of enzyme activity at low concentrations of MeHg (10(-7)-10(-6) mol/l). MeHg affects the SOD activity similarly to other mercurials which are known to react with sulfhydryl groups, and differentially influence enzymatic systems.
摘要
用甲基汞（MeHg）孵育洗涤过的猪血小板悬浮液，在MeHg浓度为10⁻⁵ - 10⁻⁴mol/l时会导致超氧化物歧化酶（SOD）活性降低。我们还观察到在低浓度MeHg（10⁻⁷ - 10⁻⁶mol/l）时酶活性增加。MeHg对SOD活性的影响与其他已知与巯基反应的汞化合物类似，并对酶系统有不同影响。
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