[唇腭裂的实验研究。VIII. 维生素A诱导Wistar大鼠腭裂]
[Experimental study on the cleft lip and palate. VIII. Induction of cleft palate in Wistar rats by vitamin A].
作者信息
Fujiwara H, Natsume N, Miura S, Inagaki S, Kanou Y, Yamamoto T, Kawai T
出版信息
Aichi Gakuin Daigaku Shigakkai Shi. 1989 Sep;27(3):629-34.
PMID:2641440
Abstract
We tried to induce cleft palate in Wistar rats by injecting Vitamin A. We injected Vitamin A into the stomach of females when they were pregnant on the eighth, ninth, tenth and eleventh day. We them sacrificed them to observe the fetuses while they were still pregnant on the eighteenth-twentieth day. The results showed that a high rate of cleft palate could be induced by injecting 5-10 x 10(4) I.U/kg of Vitamin A during pregnancy on the tenth day.
摘要
我们试图通过注射维生素A诱导Wistar大鼠腭裂。在雌性大鼠怀孕的第八、九、十和十一天时，将维生素A注入其胃内。在第十八至二十天仍处于怀孕状态时，将它们处死以观察胎儿。结果显示，在怀孕第十天注射5-10×10(4)国际单位/千克的维生素A可诱导出高比例的腭裂。
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