Pelizzo M R, Torresan F, Da Roit A, Merante Boschin I, Chondrogiannis S, Rampin L, Colletti P M, Vinjamury S, Perkins A J, Rubello D
Clinica Chirurgica 2, University School of Padova, Padova University, Padova, Italy.
Department of Nuclear Medicine, Santa Maria della Misericordia Hospital, Rovigo, Italy.
Rev Esp Med Nucl Imagen Mol. 2015 Nov-Dec;34(6):378-82. doi: 10.1016/j.remn.2015.05.007. Epub 2015 Sep 26.
Many open questions remain to be elucidated about the diagnosis, treatment and prognosis of medullary thyroid cancer (MTC). The most intriguing concerns the outcome of MTC patients after surgery. Great importance is usually given to serum calcitonin (Ct) and carcinoembryonic (CEA) levels. It is commonly believed that the higher are the levels of these tumor markers and their kinetics (double time and velocity of markers levels) the worst is the prognosis. However, this is not the rule, as there are huge MTC metastatic deposits characterized by low serum Ct and CEA levels, and this condition is not closely related to the outcome of the disease during post-surgical follow-up. A series is reported here of patients who have these characteristics, as well as a description of their prognosis and clinical outcome.
关于甲状腺髓样癌（MTC）的诊断、治疗和预后，仍有许多悬而未决的问题有待阐明。最引人关注的是MTC患者术后的结局。血清降钙素（Ct）和癌胚抗原（CEA）水平通常受到高度重视。人们普遍认为，这些肿瘤标志物的水平及其动力学（标志物水平的倍增时间和变化速度）越高，预后就越差。然而，情况并非总是如此，因为存在大量血清Ct和CEA水平较低的MTC转移灶，而且这种情况与术后随访期间疾病的结局并无密切关联。本文报告了一系列具有这些特征的患者，并描述了他们的预后和临床结局。
