新型螺母和螺栓任务可量化前驱期和症状期亨廷顿舞蹈病的运动功能障碍。
Novel Nut and Bolt Task Quantifies Motor Deficits in Premanifest and Manifest Huntington's Disease.
作者信息
Collins Lucy M, Begeti Faye, Panin Francesca, Lazar Alpar S, Cruickshank Travis, Ziman Mel, Mason Sarah L, Barker Roger A
机构信息
John van Geest Centre for Brain Repair, Cambridge, United Kingdom; Faculty of Medical Sciences, Anglia Ruskin University, Cambridge, United Kingdom.
John van Geest Centre for Brain Repair, Cambridge, United Kingdom.
出版信息
PLoS Curr. 2015 Sep 8;7:ecurrents.hd.ded251617ae62a1364506b0521bd3761. doi: 10.1371/currents.hd.ded251617ae62a1364506b0521bd3761.
BACKGROUND
We investigated the use of a simple novel nut and bolt task in premanifest and manifest Huntington's disease (HD) patients to detect and quantify motor impairments at all stages of the disease.
METHODS
Premanifest HD (n=24), manifest HD (n=27) and control (n=32) participants were asked to screw a nut onto a bolt in one direction, using three different sized bolts with their left and right hand in turn.
RESULTS
We identified some impairments at all stages of HD and in the premanifest individuals, deficits in the non-dominant hand correlated with disease burden scores.
CONCLUSION
This simple, cheap motor task was able to detect motor impairments in both premanifest and manifest HD and as such might be a useful quantifiable measure of motor function for use in clinical studies.
背景
我们研究了一种简单新颖的螺母和螺栓任务在临床前和临床期亨廷顿舞蹈症（HD）患者中的应用，以检测和量化该疾病各阶段的运动障碍。
方法
要求临床前HD患者（n = 24）、临床期HD患者（n = 27）和对照组参与者（n = 32）依次用左手和右手将螺母拧到三种不同尺寸的螺栓上，朝一个方向拧紧。
结果
我们在HD的各个阶段以及临床前个体中均发现了一些损伤，非优势手的缺陷与疾病负担评分相关。
结论
这项简单、廉价的运动任务能够检测出临床前和临床期HD患者的运动障碍，因此可能是临床研究中一种有用的运动功能量化测量方法。
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