非典型甲状旁腺腺瘤与神经纤维瘤病之间的关联。
Association between atypical parathyroid adenoma and neurofibromatosis.
作者信息
Favere Aline Mesquita Ferreira de, Tsukumo Daniela Miti, Matos Patrícia Sabino de, Santos Sérgio Luiz Marques dos, Lalli Cristina Alba
机构信息
Departamento de Clínica Médica, Faculdade de Ciências Médicas, Universidade Estadual de Campinas, Campinas, SP, Brasil.
Departamento de Anatomia Patológica, FCM, Unicamp, Campinas, SP, Brasil.
出版信息
Arch Endocrinol Metab. 2015 Oct;59(5):460-6. doi: 10.1590/2359-3997000000092. Epub 2015 Sep 25.
Primary hyperparathyroidism is a disease characterized by excessive production of parathyroid hormone (PTH), which is due to a parathyroid adenoma in 85% of cases. An atypical parathyroid adenoma, with some histopathological features of parathyroid carcinoma, may be found in some of the cases, although it may not fulfill all the criteria for this diagnosis. Neurofibromatosis type 1 (NF1) is an autosomal dominant systemic disease that may be associated with hyperparathyroidism. We report here the rare combination of a patient with NF1 and clinical manifestations of hyperparathyroidism due to an atypical parathyroid adenoma.
原发性甲状旁腺功能亢进症是一种以甲状旁腺激素（PTH）分泌过多为特征的疾病，85%的病例是由甲状旁腺腺瘤引起的。在一些病例中可能会发现具有甲状旁腺癌某些组织病理学特征的非典型甲状旁腺腺瘤，尽管它可能不符合该诊断的所有标准。1型神经纤维瘤病（NF1）是一种常染色体显性全身性疾病，可能与甲状旁腺功能亢进症有关。我们在此报告1例患有NF1且因非典型甲状旁腺腺瘤出现甲状旁腺功能亢进症临床表现的罕见病例。
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