"PEAR-ing" Genomic and Epigenomic Analyses for Cancer Gene Discovery.
作者信息
Mack Stephen C, Rich Jeremy N, Scacheri Peter C
机构信息
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio.
Department of Stem Cell Biology and Regenerative Medicine, Lerner Research Institute, Cleveland Clinic, Cleveland, Ohio. Department of Molecular Medicine, Cleveland Clinic Lerner College of Medicine of Case Western Reserve University, Cleveland, Ohio.
出版信息
Cancer Discov. 2015 Oct;5(10):1018-20. doi: 10.1158/2159-8290.CD-15-0985.
Abstract
Somatic structural variants in tumor genomes can deregulate transcription through repositioning of enhancer elements. A new method, PEAR-ChIP, leverages paired-end H3K27ac chromatin immunoprecipitation combined with high-throughput sequencing and current computational methods to identify such events.
摘要
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