较高的体重指数与代谢综合征患者动脉粥样硬化性血脂异常、胰岛素抵抗及低度炎症的增加有关。

A Larger Body Mass Index is Associated with Increased Atherogenic Dyslipidemia, Insulin Resistance, and Low-Grade Inflammation in Individuals with Metabolic Syndrome.

作者信息

Ebron Kolin, Andersen Catherine J, Aguilar David, Blesso Christopher N, Barona Jacqueline, Dugan Christine E, Jones Jennifer L, Al-Sarraj Taif, Fernandez Maria Luz

机构信息

1 Department of Nutritional Sciences, University of Connecticut , Storrs, Connecticut.

2 Department of Biology, Fairfield University , Fairfield, Connecticut.

出版信息

Metab Syndr Relat Disord. 2015 Dec;13(10):458-64. doi: 10.1089/met.2015.0053. Epub 2015 Oct 2.

DOI:10.1089/met.2015.0053

PMID:26431271

Abstract

BACKGROUND

The consequences of increased body mass index (BMI) on the metabolic disorders associated with metabolic syndrome (MetS) have not been thoroughly examined.

METHODS

We analyzed data from 262 individuals, 97 men and 165 women (aged 18-70 years), classified with MetS to investigate whether variations in BMI could be associated with parameters of dyslipidemia, insulin resistance, or low-grade inflammation. We hypothesized that increases in BMI would positively correlate with the major dysregulations in metabolism that define MetS. For this purpose, individuals were separated into four subgroups based on their BMI: normal weight (<25 kg/m(2)), overweight (≥25 to <30 kg/m(2)), obese (≥30 to <40 kg/m(2)), and morbidly obese (≥40 kg/m(2)).

RESULTS

As expected, body weight and waist circumference increased significantly as BMI increased (P < 0.0001). Both systolic and diastolic blood pressure were lower in the normal BMI group compared with the other three BMI groups (P = 0.001). Markers of HDL metabolism were adversely impacted in elevated BMI groups, as both high-density lipoprotein cholesterol (HDL-C) and large HDL decreased as BMI increased (P = 0.01). BMI was negatively correlated with HDL-C (r = -0.193, P = 0.002), HDL size (r = (-)0.227, P = 0.002), and large HDL (r = -0.147, P = 0.037). In addition, plasma insulin was highest in subjects classified as morbidly obese (P < 0.0001). There was also a strong positive correlation between BMI and plasma insulin (r = 0.413, P < 0.0001), whereas adiponectin, a marker of insulin sensitivity, was negatively correlated with BMI (r = -0.288, P = 0.001). Finally, BMI was positively correlated with proinflammatory C-reactive protein (r = 0.312, P = 0.0001) and interleukin-6 (r = 0.238, P = 0.001).

CONCLUSIONS

The data from this study suggest that the physiological factors associated with increased BMI exacerbate the metabolic abnormalities characteristic of MetS.

摘要

背景

体重指数（BMI）升高对与代谢综合征（MetS）相关的代谢紊乱的影响尚未得到充分研究。

方法

我们分析了262名个体（97名男性和165名女性，年龄在18 - 70岁之间）的数据，这些个体被归类为患有代谢综合征，以研究BMI的变化是否与血脂异常、胰岛素抵抗或低度炎症的参数相关。我们假设BMI的增加将与定义代谢综合征的主要代谢失调呈正相关。为此，根据BMI将个体分为四个亚组：正常体重（<25 kg/m²）、超重（≥25至<30 kg/m²）、肥胖（≥30至<40 kg/m²）和病态肥胖（≥40 kg/m²）。

结果

正如预期的那样，随着BMI的增加，体重和腰围显著增加（P < 0.0001）。正常BMI组的收缩压和舒张压均低于其他三个BMI组（P = 0.001）。在BMI升高的组中，高密度脂蛋白（HDL）代谢标志物受到不利影响，因为随着BMI增加，高密度脂蛋白胆固醇（HDL-C）和大颗粒HDL均降低（P = 0.01）。BMI与HDL-C（r = -0.193，P = 0.002）、HDL大小（r = (-)0.227，P = 0.002）和大颗粒HDL（r = -0.147，P = 0.037）呈负相关。此外，病态肥胖受试者的血浆胰岛素最高（P < 0.0001）。BMI与血浆胰岛素之间也存在很强的正相关（r = 0.413，P < 0.0001），而胰岛素敏感性标志物脂联素与BMI呈负相关（r = -0.288，P = 0.001）。最后，BMI与促炎C反应蛋白（r = 0.312，P = 0.0001）和白细胞介素-6（r = 0.238，P = 0.001）呈正相关。