金黄色葡萄球菌血流感染患者的死亡危险因素。
Risk factors for mortality in patients with Staphylococcus aureus bloodstream infection.
作者信息
De Rosa Francesco Giuseppe, Corcione Silvia, Motta Ilaria, Petrolo Alessia, Filippini Claudia, Pagani Nicole, Fossati Lucina, Cavallo Rossana, Di Perri Giovanni
机构信息
a Department of Medical Sciences , University of Turin, Infectious Diseases at Amedeo di Savoia Hospital , Turin , Italy.
b Department of Surgical Sciences , University of Turin, Division of Anaesthesia and Critical Care, City of Health and Science, Molinette Hospital , Turin , Italy.
出版信息
J Chemother. 2016 Jun;28(3):187-90. doi: 10.1179/1973947815Y.0000000076. Epub 2016 May 30.
In this two year retrospective analysis, we evaluated the epidemiology and risk factors for mortality of Staphylococcus aureus bloodstream infection (SaBSI). Methicillin-susceptible S. aureus (MSSA) was isolated in 84 (44.2%) and methicillin-resistant S. aureus (MRSA) in 106 episodes (55.8%). The mortality rate after 21 days was 16.4%. At univariate analysis older age, no removal of central venous catheter (CVC), prosthetic heart valves, severe sepsis, septic shock and high APACHE II score were significantly associated with mortality, whereas treatment duration > 48 hours, appropriate targeted therapy and prolonged treatment duration were significantly associated with survival. At multivariate analysis, prosthetic valves, septic shock and fever 48 hours after the diagnosis were significantly related to mortality. In this study, the mortality was associated with clinical rather than microbiological factors.
在这项为期两年的回顾性分析中，我们评估了金黄色葡萄球菌血流感染（SaBSI）的流行病学及死亡风险因素。甲氧西林敏感金黄色葡萄球菌（MSSA）在84例（44.2%）中分离得到，甲氧西林耐药金黄色葡萄球菌（MRSA）在106例（55.8%）中分离得到。21天后的死亡率为16.4%。单因素分析显示，年龄较大、未拔除中心静脉导管（CVC）、人工心脏瓣膜、严重脓毒症、感染性休克及较高的急性生理与慢性健康状况评分系统（APACHE II）评分与死亡率显著相关，而治疗持续时间>48小时、适当的靶向治疗及延长治疗持续时间与生存显著相关。多因素分析显示，人工瓣膜、感染性休克及诊断后48小时发热与死亡率显著相关。在本研究中，死亡率与临床因素而非微生物学因素相关。
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