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[体外光化学疗法的最新进展]

[Update on extracorporeal photopheresis].

作者信息

Just U, Knobler R

机构信息

Universitätsklinik für Dermatologie, Medizinische Universität Wien, Währinger Gürtel 18-20, 1090, Wien, Österreich.

出版信息

Hautarzt. 2015 Nov;66(11):804-9. doi: 10.1007/s00105-015-3702-1.

Abstract

Extracorporeal photopheresis (ECP) is a treatment approach that combines leukapheresis with photochemotherapy and is derived from PUVA; with this procedure, nucleated cells such as lymphocytes and monocytes are extracorporeally irradiated with UVA light after photosensitization. ECP is an effective treatment modality with few side effects that in recent years has been expanded to treat a range of indications. It has been proven effective in the treatment of cutaneous T cell lymphoma and is being increasing used in other lymphocyte-mediated, autoimmune and inflammatory diseases that are associated with proliferation of autoreactive T cells.

摘要

体外光化学疗法(ECP)是一种将白细胞单采术与光化学疗法相结合的治疗方法,源自补骨脂素紫外线A光化学疗法(PUVA);通过该程序,淋巴细胞和单核细胞等有核细胞在光敏化后用紫外线A光进行体外照射。ECP是一种副作用较少的有效治疗方式,近年来已扩展到治疗一系列适应症。它已被证明对皮肤T细胞淋巴瘤有效,并越来越多地用于其他与自身反应性T细胞增殖相关的淋巴细胞介导的自身免疫性和炎性疾病。

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