Chanta Chulapong, Phloenchaiwanit Piti
J Med Assoc Thai. 2015 Aug;98(8):756-60.
To evaluate the efficacy and safety of azithromycinfor treatment of uncomplicated pediatric scrub typhus.
A randomized controlled trial was performed. We compared azithromycin with doxycycline or chloramphenicol in uncomplicated pediatric scrub typhus from inpatient pediatric department of Chiangrai Prachanukroh Hospital. The primary outcome was cure rate at day 3. The secondary outcomes were timing to defervescence within 72 hours, side effects, and relapsed rate. We compared data between both groups with Fisher's exact test or Mann-Whitney U test, and failure rate was demonstrated by Kaplan-Meier survival curve and Log-rank test.
We included 57 patients, ofwhom, 28 were assigned to doxycycline or chloramphenicol (control group) and 29 to azithromycin (study group). The baseline characteristics of both groups were similar The cure rate was 85.7% in the doxycycline or chloramphenicol group, as compared to 79.3% in the azithromycin group (p = 0.73), and a median time to defervescence was 30 hours (IQR 21, 48) vs. 36 hours (IQR 20, 68) respectively (p = 0.166). There was a little minor side effect in azithromycin group. No relapsed was found in either groups.
Azithromycin was as effective as doxycycline or chloramphenicol in treatment of uncomplicated pediatric scrub typhus.
评估阿奇霉素治疗儿童轻症恙虫病的疗效和安全性。
进行一项随机对照试验。我们将清莱普拉查努克罗医院儿科住院部的儿童轻症恙虫病患者中阿奇霉素与强力霉素或氯霉素进行比较。主要结局是第3天的治愈率。次要结局是72小时内退热时间、副作用和复发率。我们使用Fisher精确检验或Mann-Whitney U检验比较两组数据，失败率通过Kaplan-Meier生存曲线和对数秩检验显示。
我们纳入了57例患者，其中28例被分配到强力霉素或氯霉素组（对照组），29例被分配到阿奇霉素组（研究组）。两组的基线特征相似。强力霉素或氯霉素组的治愈率为85.7%，而阿奇霉素组为79.3%（p = 0.73），退热的中位时间分别为30小时（IQR 21，48）和36小时（IQR 20，68）（p = 0.166）。阿奇霉素组有一些轻微的副作用。两组均未发现复发。
阿奇霉素在治疗儿童轻症恙虫病方面与强力霉素或氯霉素一样有效。
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