Peng Xian-E, Wu Yun-Li, Zhu Yi-Bing, Huang Rong-Dong, Lu Qing-Qing, Lin Xu
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Department of Epidemiology and Health Statistics, School of Public Health, Fujian Medical University, Fuzhou, China.
Key Laboratory of Ministry of Education for Gastrointestinal Cancer, School of Basic Medical Sciences, Fujian Medical University, Fuzhou, China; Fujian Key Laboratory of Tumor Microbiology, Department of Medical Microbiology, Fujian Medical University, Fuzhou, China.
PLoS One. 2015 Oct 6;10(10):e0139417. doi: 10.1371/journal.pone.0139417. eCollection 2015.
Liver fatty acid-binding protein (L-FABP), also known as fatty acid-binding protein 1 (FABP1), is a key regulator of hepatic lipid metabolism. Elevated FABP1 levels are associated with an increased risk of cardiovascular disease (CVD) and metabolic syndromes. In this study, we examine the association of FABP1 gene promoter variants with serum FABP1 and lipid levels in a Chinese population. Four promoter single-nucleotide polymorphisms (SNPs) of FABP1 gene were genotyped in a cross-sectional survey of healthy volunteers (n = 1,182) from Fuzhou city of China. Results showed that only the rs2919872 G>A variant was significantly associated with serum TG concentration(P = 0.032).Compared with the rs2919872 G allele, rs2919872 A allele contributed significantly to reduced serum TG concentration, and this allele dramatically decreased the FABP1 promoter activity(P < 0.05). The rs2919872 A allele carriers had considerably lower serum FABP1 levels than G allele carriers (P < 0.01). In the multivariable linear regression analysis, the rs2919872 A allele was negatively associated with serum FABP1 levels (β = -0.320, P = 0.003), while serum TG levels were positively associated with serum FABP1 levels (β = 0.487, P = 0.014). Our data suggest that compared with the rs2919872 G allele, the rs2919872 A allele reduces the transcriptional activity of FABP1 promoter, and thereby may link FABP1 gene variation to TG level in humans.
肝脏脂肪酸结合蛋白（L-FABP），也称为脂肪酸结合蛋白1（FABP1），是肝脏脂质代谢的关键调节因子。FABP1水平升高与心血管疾病（CVD）和代谢综合征风险增加相关。在本研究中，我们检测了中国人群中FABP1基因启动子变异与血清FABP1及血脂水平的关联。对来自中国福州市的1182名健康志愿者进行横断面调查，对FABP1基因的4个启动子单核苷酸多态性（SNP）进行基因分型。结果显示，只有rs2919872 G>A变异与血清甘油三酯（TG）浓度显著相关（P = 0.032）。与rs2919872 G等位基因相比，rs2919872 A等位基因对降低血清TG浓度有显著作用，且该等位基因显著降低了FABP1启动子活性（P < 0.05）。rs2919872 A等位基因携带者的血清FABP1水平显著低于G等位基因携带者（P < 0.01）。在多变量线性回归分析中，rs2919872 A等位基因与血清FABP1水平呈负相关（β = -0.320，P = 0.003），而血清TG水平与血清FABP1水平呈正相关（β = 0.487，P = 0.014）。我们的数据表明，与rs2919872 G等位基因相比，rs2919872 A等位基因降低了FABP1启动子的转录活性，从而可能将FABP1基因变异与人类TG水平联系起来。
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