小鼠动脉粥样硬化中的细胞因子与免疫反应

Cytokines and Immune Responses in Murine Atherosclerosis.

作者信息

Kusters Pascal J H, Lutgens Esther

机构信息

Department of Medical Biochemistry, Academic Medical Center, Amsterdam, The Netherlands.

Department of Medical Biochemistry, Academic Medical Center, L01-146.1, University of Amsterdam, Meibergdreef 9, 1105 AZ, Amsterdam, The Netherlands.

出版信息

Methods Mol Biol. 2015;1339:17-40. doi: 10.1007/978-1-4939-2929-0_2.

DOI:10.1007/978-1-4939-2929-0_2

PMID:26445779

Abstract

Atherosclerosis is an inflammatory disease of the vessel wall characterized by activation of the innate immune system, with macrophages as the main players, as well as the adaptive immune system, characterized by a Th1-dominant immune response. Cytokines play a major role in the initiation and regulation of inflammation. In recent years, many studies have investigated the role of these molecules in experimental models of atherosclerosis. While some cytokines such as TNF or IFNγ clearly had atherogenic effects, others such as IL-10 were found to be atheroprotective. However, studies investigating the different cytokines in experimental atherosclerosis revealed that the cytokine system is complex with both disease stage-dependent and site-specific effects. In this review, we strive to provide an overview of the main cytokines involved in atherosclerosis and to shed light on their individual role during atherogenesis.

摘要

动脉粥样硬化是一种血管壁炎症性疾病，其特征是先天性免疫系统激活，巨噬细胞是主要参与者，同时也是适应性免疫系统激活，其特征是以Th1为主导的免疫反应。细胞因子在炎症的启动和调节中起主要作用。近年来，许多研究调查了这些分子在动脉粥样硬化实验模型中的作用。虽然一些细胞因子如TNF或IFNγ明显具有致动脉粥样硬化作用，但其他细胞因子如IL-10被发现具有抗动脉粥样硬化保护作用。然而，在实验性动脉粥样硬化中研究不同细胞因子的研究表明，细胞因子系统很复杂，具有疾病阶段依赖性和位点特异性效应。在这篇综述中，我们力求概述参与动脉粥样硬化的主要细胞因子，并阐明它们在动脉粥样硬化发生过程中的各自作用。