Wu Jin, Hu Lixia, Du Yingying, Kong Fanliang, Pan Yueyin
The Central Laboratory, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui, People's Republic of China.
Department of Oncology, The Second People's Hospital of Hefei, Hefei, Anhui, People's Republic of China.
Onco Targets Ther. 2015 Sep 15;8:2565-70. doi: 10.2147/OTT.S89597. eCollection 2015.
The prognostic value of lysine-specific demethylase 1 (LSD1) overexpression in various cancers has been investigated by many studies with inconsistent results. A meta-analysis was performed to assess the association between LSD1 and overall survival (OS) in cancer patients. Eligible studies were identified by searching the online databases PubMed and China National Knowledge Infrastructure up to February 2015. Hazard ratios (HRs) with 95% confidence intervals (CIs) were calculated to clarify the correlation between LSD1 expression and prognosis of different cancers. In total, nine studies with 1,149 cancer patients were included for final analysis. The meta-analysis suggested that LSD1 overexpression was associated with poor OS in cancer patients (HR =1.80, 95% CI: 1.39-2.34, P=0.000). Subgroup analysis by ethnicity, cancer type and HR estimate also showed that high levels of LSD1 were significantly correlated with OS. The meta-analysis showed that LSD1 overexpression may be associated with a worse prognosis in cancer patients.
许多研究已对赖氨酸特异性去甲基化酶1（LSD1）过表达在多种癌症中的预后价值进行了调查，但结果并不一致。进行了一项荟萃分析，以评估LSD1与癌症患者总生存期（OS）之间的关联。通过检索在线数据库PubMed和中国知网，截至2015年2月确定了符合条件的研究。计算了具有95%置信区间（CI）的风险比（HR），以阐明LSD1表达与不同癌症预后之间的相关性。总共纳入了9项研究中的1149例癌症患者进行最终分析。荟萃分析表明，LSD1过表达与癌症患者较差的总生存期相关（HR = 1.80，95% CI：1.39 - 2.34，P = 0.000）。按种族、癌症类型和HR估计进行的亚组分析还表明，LSD1水平升高与总生存期显著相关。荟萃分析表明，LSD1过表达可能与癌症患者更差的预后相关。
Zotero 插件
