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变应原免疫疗法(AIT):“精准医学”的一个典范。

AIT (allergen immunotherapy): a model for the "precision medicine".

作者信息

Passalacqua Giovanni, Canonica Giorgio Walter

机构信息

Allergy and Respiratory Diseases, Department of Internal Medicine, S. Martino Hospital, IRCCS San Martino-IST-University of Genoa, Pad.Maragliano, L.go R Benzi 10, 16133 Genoa, Italy.

出版信息

Clin Mol Allergy. 2015 Oct 8;13:24. doi: 10.1186/s12948-015-0028-6. eCollection 2015.

Abstract

The interpretation of medical approaches, especially therapy, evolved rapidly in the last century. Starting from the simple description of symptoms, we moved to the pathophysiological descriptions, to the evidence-based medicine, until the so-called "precision medicine". This latter can be defined as a structural model aimed at customizing healthcare, with medical decisions/products tailored on an individual patient at a highly detailed level. In this sense, allergen immunotherapy represents an optimal model of "precision medicine", since we know and describe symptoms, function, aetiological agents at molecular level, and we have the possibility to intervene on the natural history of the disease. If considered under the point of view of pharmaco-economy, that is prescribing the optimal treatment to the right patient, allergen immunotherapy represents an almost-ideal model of precision medicine.

摘要

医学方法,尤其是治疗方法的解释,在上个世纪迅速发展。从对症状的简单描述开始,我们转向病理生理学描述,再到循证医学,直至所谓的“精准医学”。后者可被定义为一种旨在定制医疗保健的结构模型,医疗决策/产品是在非常详细的层面上针对个体患者量身定制的。从这个意义上讲,变应原免疫疗法代表了“精准医学”的一个最佳模型,因为我们在分子水平上了解并描述症状、功能、致病因子,而且我们有可能对疾病的自然病程进行干预。从药物经济学的角度来看,即给合适的患者开最佳治疗方案,变应原免疫疗法代表了一种近乎理想的精准医学模型。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/e891/4597399/2bcc634f45bb/12948_2015_28_Fig1_HTML.jpg

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