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1例格雷夫斯病患者伴淋巴结转移的甲状腺乳头状癌沃辛变异型的不寻常表现

Unusual presentation of Warthin variant of Papillary thyroid carcinoma with lymph nodal metastases in a patient of Graves' disease.

作者信息

Padma Subramanyam, Sundaram Palaniswamy Shanmuga, Arun B R

机构信息

Department of Nuclear Medicine and PET CT, Amrita Institute of Medical Sciences, Amrita Vishwa Vidyapeetham University, Cochin, Kerala, India.

出版信息

J Cancer Res Ther. 2015 Jul-Sep;11(3):652. doi: 10.4103/0973-1482.138041.

Abstract

Warthin-like Papillary thyroid carcinoma (WPTC) is a rare variant of papillary carcinoma of thyroid, PTC which derives its name by closely resembling Warthin's tumor of salivary gland. Hallmark histological feature of this variant is papillary folding lined by oncocytic neoplastic cells with clear nuclei and nuclear pseudoinclusions, accompanied by prominent lymphocytic infiltrate in the papillary stalks. It is thought to be one of those differentiated thyroid cancers with favorable prognosis. We report a case of Graves' disease with a cold nodule harboring WPTC with initial presentation of lymph nodal metastases. It is important to identify this peculiar variant of PTC as 5 to 10% of them undergo dedifferentiation and 30% have the lymph nodal metastases and extra thyroidal extension.

摘要

沃辛样甲状腺乳头状癌(WPTC)是甲状腺乳头状癌(PTC)的一种罕见变体,因其与涎腺沃辛瘤极为相似而得名。该变体的标志性组织学特征是由具有透明细胞核和核假包涵体的嗜酸性肿瘤细胞排列成的乳头状折叠,伴有乳头柄中显著的淋巴细胞浸润。它被认为是预后良好的分化型甲状腺癌之一。我们报告了1例伴有冷结节的格雷夫斯病病例,该冷结节内含有WPTC,最初表现为淋巴结转移。识别这种特殊的PTC变体很重要,因为其中5%至10%会发生去分化,30%会出现淋巴结转移和甲状腺外扩展。

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