在伴有颈内动脉狭窄的2型糖尿病患者中，血清成纤维细胞生长因子23（FGF23）水平升高与不稳定颈动脉斑块相关。

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

作者信息

Biscetti Federico, Straface Giuseppe, Porreca Carlo Filippo, Bertoletti Giovanni, Vincenzoni Claudio, Snider Francesco, Stigliano Egidio, Arena Vincenzo, Angelini Flavia, Pecorini Giovanni, Bianchi Antonio, Landolfi Raffaele, Flex Andrea

机构信息

Institute of Rheumatology and Affine Sciences, Catholic University School of Medicine, Rome, Italy.

Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy.

出版信息

Cardiovasc Diabetol. 2015 Oct 12;14:139. doi: 10.1186/s12933-015-0301-5.

DOI:10.1186/s12933-015-0301-5

PMID:26459301

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4603970/

Abstract

BACKGROUND

The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.

METHODS

In this retrospective observational study, we analyzed FGF23 serum level in 361 type 2 diabetic patients with internal carotid artery stenosis undergoing carotid endarterectomy and in 598 diabetic controls without carotid atherosclerosis.

RESULTS

We found that FGF23 median serum levels was significantly higher in patients than in diabetic controls [67.7 (59.5-77.8) pg/mL and 43.89 (37.5-50.4), P < 0.001] and was significantly and independently associated with unstable plaque in patients with internal carotid artery stenosis [OR, 5,71 (95% CI, 2.09-15.29].

CONCLUSIONS

We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

摘要

背景

本研究的目的是探讨成纤维细胞生长因子23（FGF23）在2型糖尿病合并颈内动脉狭窄患者斑块稳定性中的潜在作用。

方法

在这项回顾性观察研究中，我们分析了361例接受颈动脉内膜切除术的2型糖尿病合并颈内动脉狭窄患者和598例无颈动脉粥样硬化的糖尿病对照者的血清FGF23水平。

结果

我们发现，患者的FGF23血清中位数水平显著高于糖尿病对照组[分别为67.7（59.5 - 77.8）pg/mL和43.89（37.5 - 50.4），P < 0.001]，并且在颈内动脉狭窄患者中与不稳定斑块显著且独立相关[比值比（OR）为5.71（95%置信区间为2.09 - 15.29）]。

结论

我们首次发现，FGF23可能与2型糖尿病合并颈内动脉狭窄患者的不稳定斑块有关。

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在伴有颈内动脉狭窄的2型糖尿病患者中，血清成纤维细胞生长因子23（FGF23）水平升高与不稳定颈动脉斑块相关。

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

作者信息

机构信息

Institute of Rheumatology and Affine Sciences, Catholic University School of Medicine, Rome, Italy.

Laboratory of Vascular Biology and Genetics, Catholic University School of Medicine, Rome, Italy.

出版信息

Cardiovasc Diabetol. 2015 Oct 12;14:139. doi: 10.1186/s12933-015-0301-5.

DOI:10.1186/s12933-015-0301-5

PMID:26459301

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4603970/

Abstract

BACKGROUND

The object of this study was to investigate the potential role of FGF23 on plaque stability in type 2 diabetic patients with internal carotid artery stenosis.

METHODS

RESULTS

CONCLUSIONS

We have found, for the first time, that FGF23 could be associated with unstable plaque in type 2 diabetic patients with internal carotid artery stenosis.

摘要

背景

本研究的目的是探讨成纤维细胞生长因子23（FGF23）在2型糖尿病合并颈内动脉狭窄患者斑块稳定性中的潜在作用。

方法

结果

结论

我们首次发现，FGF23可能与2型糖尿病合并颈内动脉狭窄患者的不稳定斑块有关。

在伴有颈内动脉狭窄的2型糖尿病患者中，血清成纤维细胞生长因子23（FGF23）水平升高与不稳定颈动脉斑块相关。

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

作者信息

机构信息

出版信息

BACKGROUND

METHODS

RESULTS

CONCLUSIONS

背景

方法

结果

结论

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在伴有颈内动脉狭窄的2型糖尿病患者中，血清成纤维细胞生长因子23（FGF23）水平升高与不稳定颈动脉斑块相关。

Increased FGF23 serum level is associated with unstable carotid plaque in type 2 diabetic subjects with internal carotid stenosis.

作者信息

机构信息

出版信息

BACKGROUND

METHODS

RESULTS

CONCLUSIONS

背景

方法

结果

结论