Rogers Jonathan, Mirams Jamie, Patel Rashmi
Medical Academic Unit, Broomfield Hospital, Court Road, Chelmsford, Essex CM1 7ET, United Kingdom.
Medical Academic Unit, Broomfield Hospital, Court Road, Chelmsford, Essex CM1 7ET, United Kingdom.
Med Hypotheses. 2015 Dec;85(6):858-62. doi: 10.1016/j.mehy.2015.09.023. Epub 2015 Sep 28.
Bipolar disorder, characterised by extreme cyclical variations in mood between depression and mania, is a common, debilitating and sometimes fatal psychiatric condition with an unclear aetiology. In this paper we propose a hypothesis for the development of bipolar disorder through which neuroplastic changes in response to an index depressive episode leads to the amplification of subthreshold pleasurable stimuli that then drive conversion into a manic state. This 'pleasure deafferentation hypothesis' is reached through a discussion of the neuroscientific basis of deafferentation at the level of the neuron and its role in the development of various neurological and psychiatric phenomena before a case for deafferentation as applied to bipolar disorder is justified and its implications discussed.
双相情感障碍的特征是情绪在抑郁和躁狂之间呈现极端的周期性变化，它是一种常见、使人衰弱且有时致命的精神疾病，病因尚不明确。在本文中，我们提出了一个关于双相情感障碍发病机制的假说，即对首次抑郁发作的反应所导致的神经可塑性变化会使阈下愉悦刺激增强，进而促使转变为躁狂状态。这个“愉悦传入阻滞假说”是通过在神经元层面讨论传入阻滞的神经科学基础及其在各种神经和精神现象发生过程中的作用而得出的，随后阐述了将传入阻滞应用于双相情感障碍的理由并讨论了其意义。
