低表达的PBRM1可识别乳腺癌的肿瘤进展和不良预后。
Low PBRM1 identifies tumor progression and poor prognosis in breast cancer.
作者信息
Mo Dan, Li Chunhong, Liang Junrong, Shi Qunfeng, Su Naiwei, Luo Shuyou, Zeng Tian, Li Xinning
机构信息
Department of Surgery, Maternal and Child Health Hospital of Guangxi Zhuang Autonomous Region Nanning, China.
Public Health College of Guangxi Medical University Nanning, China.
出版信息
Int J Clin Exp Pathol. 2015 Aug 1;8(8):9307-13. eCollection 2015.
BACKGROUND
To investigate the expression and role of PBRM1 in breast cancer, and to evaluate the clinical and prognostic significance of PBRM1 protein in patients with breast cancer.
METHODS
The expression of PBRM1 was examined in breast cancer tissue and paired non-cancerous tissues by real-time PCR. Moreover, PBRM1 protein expression was evaluated by immunohistochemistry in 150 paraffin-embedded breast cancer specimens. The correlation between PBRM1 expression and clinicopathological features were statistically analyzed.
RESULTS
The status of PBRM1 protein in breast cancer tissues is much lower than that in paracarcinoma tissues. Low PBRM1 expression was positively correlated with tumor stage (P =0.003) and lymph node metastasis (P =0.013). The overall (P =0.003) and recurrent-free survival (P =0.001) of the patients with high PBRM1 expression was significantly lower than the low PBRM1 expression group. Multivariate analysis showed that the expression of PBRM1 was an independent factor of overall survival for the patients with breast cancer (P =0.030).
CONCLUSIONS
PBRM1 might involve in the development and progression of breast cancer as a tumor suppressor, and thereby may be a valuable prognostic marker for breast cancer patients.
背景
探讨PBRM1在乳腺癌中的表达及作用，评估PBRM1蛋白在乳腺癌患者中的临床及预后意义。
方法
采用实时荧光定量PCR检测乳腺癌组织及配对癌旁组织中PBRM1的表达。此外，应用免疫组织化学法对150例石蜡包埋的乳腺癌标本进行PBRM1蛋白表达评估。对PBRM1表达与临床病理特征之间的相关性进行统计学分析。
结果
乳腺癌组织中PBRM1蛋白水平明显低于癌旁组织。PBRM1低表达与肿瘤分期（P =0.003）及淋巴结转移（P =0.013）呈正相关。PBRM1高表达患者的总生存期（P =0.003）和无复发生存期（P =0.001）显著低于PBRM1低表达组。多因素分析显示，PBRM1表达是乳腺癌患者总生存的独立影响因素（P =0.030）。
结论
PBRM1可能作为抑癌基因参与乳腺癌的发生发展，有望成为乳腺癌患者有价值的预后标志物。
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