Lehrman Mark A
Department Pharmacology, UT-Southwestern Medical Center at Dallas, Dallas, TX, USA.
Trends Biochem Sci. 2015 Dec;40(12):715-717. doi: 10.1016/j.tibs.2015.10.001. Epub 2015 Oct 17.
The mechanism for flipping large lipid-linked oligosaccharides across membranes has remained a paradox. Perez et al. now report the structure of the PglK protein of C. jejuni, a flippase for a bacterial lipid-linked oligosaccharide, and reveal an unexpected whip-like mechanism.
将大型脂质连接寡糖翻转穿过膜的机制一直是个谜。佩雷斯等人现在报告了空肠弯曲杆菌PglK蛋白的结构,该蛋白是一种细菌脂质连接寡糖的翻转酶,并揭示了一种意想不到的鞭状机制。