A Practical One-Pot Synthesis of Positron Emission Tomography (PET) Tracers via Nickel-Mediated Radiofluorination.
作者信息
Zlatopolskiy Boris D, Zischler Johannes, Urusova Elizaveta A, Endepols Heike, Kordys Elena, Frauendorf Holm, Mottaghy Felix M, Neumaier Bernd
机构信息
Institute of Radiochemistry & Experimental Molecular Imaging, University Clinic Cologne Kerpener Str. 62, 50937, Cologne, Germany ; Max Planck Institute for Metabolism Research Gleueler Str. 50, 50931, Cologne, Germany.
Institute of Radiochemistry & Experimental Molecular Imaging, University Clinic Cologne Kerpener Str. 62, 50937, Cologne, Germany ; Max Planck Institute for Metabolism Research Gleueler Str. 50, 50931, Cologne, Germany ; Clinic of Nuclear Medicine, RWTH Aachen University Pauwelsstraße 30, 52074, Aachen, Germany.
出版信息
ChemistryOpen. 2015 Aug;4(4):395. doi: 10.1002/open.201500144. Epub 2015 Aug 13.
Invited for this months cover picture is the group of Professor Bernd Neumaier at the Institute of Radiochemistry and Experimental Molecular Imaging at the University Clinic of Cologne. The cover picture shows the differences in brain metabolism of a healthy young and a healthy old subject, as well as a patient suffering from Parkinsons disease (left to right) uncovered by 6-[(18)F]FDOPA-positron emission tomography (PET). Morbus Parkinson occurs when nerve cells that produce dopamine begin to die. The shortage of dopamine leads to movement problems in affected individuals. 6-[(18)F]FDOPA is extensively used to evaluate the progression of Parkinsons disease. Bold stick projections of this PET tracer, as well as a neuronal network, are seen in the background. Unfortunately, conventional procedures to produce 6-[(18)F]FDOPA are cumbersome. Thus, several recent developments aim at the simplification of this radiosynthesis. In our work, we studied the applicability of the recently reported Ni-mediated radiofluorination approach for daily routine production of 6-[(18)F]FDOPA. For more details, see the Full Paper on p. 457 ff.
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