Cheslow Lara, Alvarez Jorge Iván
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Department of Pathobiology, School of Veterinary Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Curr Opin Pharmacol. 2016 Feb;26:39-46. doi: 10.1016/j.coph.2015.09.010. Epub 2015 Oct 19.
The blood-brain barrier (BBB) is comprised of unique endothelial cells (ECs) that regulate the delicate central nervous system (CNS) microenvironment. During development, vasculature sprouts from the perivascular neural plexus and penetrates the CNS parenchyma. Recent studies indicate that these nascent vessels rely on radial glia (RG)-secreted factors for guidance and barrier induction. This early association also sustains astrocyte development, allowing for a tight interaction between these mature glia and ECs. The astrocyte-EC interface is crucial to BBB function and is substantially modified during pathology. Understanding the relationship between astrocytes and ECs lays the groundwork for advancing protective therapies that target neuroinflammatory disorders.
血脑屏障（BBB）由独特的内皮细胞（ECs）组成，这些内皮细胞调节着脆弱的中枢神经系统（CNS）微环境。在发育过程中，血管从血管周围神经丛中萌芽并穿透CNS实质。最近的研究表明，这些新生血管依靠放射状胶质细胞（RG）分泌的因子进行引导和诱导屏障形成。这种早期关联也维持了星形胶质细胞的发育，使得这些成熟的胶质细胞与内皮细胞之间能够紧密相互作用。星形胶质细胞 - 内皮细胞界面对于血脑屏障功能至关重要，并且在病理过程中会发生显著改变。了解星形胶质细胞与内皮细胞之间的关系为推进针对神经炎症性疾病的保护性治疗奠定了基础。
