Li Xiaokang, Ni Wei, Mao Fei, Wang Wei, Li Jian
Shanghai Key Laboratory of New Drug Design, School of Pharmacy, East China University of Science and Technology, 130 Meilong Road, Shanghai, 200237, China.
Department of Chemistry and Chemical Biology, University of New Mexico, Albuquerque, NM, 87131-0001, USA.
Chem Asian J. 2016 Jan;11(2):226-30. doi: 10.1002/asia.201500854. Epub 2015 Nov 3.
A mild, metal-free approach has been realized for the facile construction of highly valuable 3-(hetero)aryl-3-hydroxy-2-oxindoles. Direct arylations of 3-acyloxy-2-oxindoles with diaryliodonium salts as arylation reagents are implemented in the presence of K2 CO3 at room temperature without using an organometallic promoter to deliver an array of 3-(hetero)aryl-3-hydroxy-2-oxindoles in good yields.
已实现一种温和的无金属方法，用于简便构建高价值的3-（杂）芳基-3-羟基-2-吲哚酮。以二芳基碘鎓盐作为芳基化试剂，在碳酸钾存在下于室温实现3-酰氧基-2-吲哚酮的直接芳基化，无需使用有机金属促进剂，即可高产率地得到一系列3-（杂）芳基-3-羟基-2-吲哚酮。
Zotero 插件