基因长度起作用吗？——应激条件下Gcn5组蛋白乙酰转移酶的瞬时调控

Does gene length play a role? - Transient regulation of Gcn5 histone acetyltransferase under stress conditions.

作者信息

Xue-Franzén Yongtao

机构信息

Department of Neuroscience, Karolinska Institutet., Scheelesväg 1, 171 77 Stockholm, Sweden.

出版信息

Genom Data. 2014 Sep 8;2:293-5. doi: 10.1016/j.gdata.2014.09.001. eCollection 2014 Dec.

DOI:10.1016/j.gdata.2014.09.001

PMID:26484112

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4535997/

Abstract

Gcn5 is a histone modification enzyme that performs its function by global or locus-specific histone acetylation. It is known that Gcn5 involves in stress responses in yeast. Our previous data showed that Gcn5 relocalized to the long genes under IM KCl stress conditions in yeast. Here we use a stress adaptation and recovery model and performed 52 microarrays. By investigating the gene regulation pattern, genome-wide localization of Gcn5, as well as histone modification, we aim to understand the regulation mechanism. The data is available in Gene Expression Omnibus (GEO: SuperSeriesGSE 36601).

摘要

Gcn5是一种组蛋白修饰酶，通过全局或位点特异性组蛋白乙酰化发挥其功能。已知Gcn5参与酵母中的应激反应。我们之前的数据表明，在酵母的IM KCl应激条件下，Gcn5会重新定位到长基因上。在这里，我们使用应激适应和恢复模型并进行了52次微阵列实验。通过研究基因调控模式、Gcn5的全基因组定位以及组蛋白修饰，我们旨在了解调控机制。数据可在基因表达综合数据库（GEO：超级系列GSE 36601）中获取。